Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Radiol. Nov 28, 2015; 7(11): 375-381
Published online Nov 28, 2015. doi: 10.4329/wjr.v7.i11.375
Iliac vein compression syndrome: Clinical, imaging and pathologic findings
Katelyn N Brinegar, Rahul A Sheth, Ali Khademhosseini, Jemianne Bautista, Rahmi Oklu
Katelyn N Brinegar, Rahul A Sheth, Jemianne Bautista, Division of Interventional Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, United States
Ali Khademhosseini, Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA 02139, United States
Ali Khademhosseini, Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, United States
Ali Khademhosseini, Rahmi Oklu, Biomaterials Innovation Research Center, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02139, United States
Rahmi Oklu, Division of Interventional Radiology, Mayo Clinic, Scottsdale, AZ 85054, United States
Author contributions: Brinegar KN, Sheth RA, Khademhosseini A, Bautista J and Oklu R conceived the issues which formed the content of the manuscript and equally aided in its writing, editing, and revising.
Conflict-of-interest statement: The authors declared no conflicts of interest and have no financial disclosures.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Correspondence to: Rahmi Oklu, MD, PhD, Division of Interventional Radiology, Mayo Clinic, 5777 E Mayo Blvd, Scottsdale, AZ 85054, United States.
Telephone: +1-480-3421650 Fax: +1-480-3421650
Received: May 6, 2015
Peer-review started: May 8, 2015
First decision: July 10, 2015
Revised: August 3, 2015
Accepted: September 10, 2015
Article in press: September 16, 2015
Published online: November 28, 2015
Core Tip

Core tip: There is currently no gold standard diagnostic criterion in iliac vein compression syndrome. Historically, the presence of pathologic factors has been the main component in diagnosis; however, imaging techniques have led to a more radiologic-based diagnosis. This review details the clinical and radiologic challenges in the diagnosis of Iliac vein compression syndrome and presents clinical pearls that may help in deciding whether an endovascular intervention should be performed.