Published online Jul 28, 2014. doi: 10.4329/wjr.v6.i7.459
Revised: April 25, 2014
Accepted: May 16, 2014
Published online: July 28, 2014
Core tip: The development of novel nanomaterials specifically targeting diseased cells has made possible their employment as nanosized contrast agents also for non-ionizing molecular imaging techniques namely, magnetic resonance, ultrasound and optical imaging. Among them, ultrasound imaging might represent the best choice because of its low cost, ease of use and wide availability in clinical practice. Unfortunately, their actual employment in molecular imaging is limited due to their low tissue contrast discrimination. Hence, the described development of novel ultrasound targeted contrast agent may play a crucial role for their use in clinical molecular imaging.