Singh SP, Varghese KJ, Qureshi FM, Anderson MC, Foxworth J, Knuepfer MM. Catheter-based renal sympathetic nerve denervation on hypertension management outcomes. World J Radiol 2022; 14(7): 238-248 [PMID: 36160631 DOI: 10.4329/wjr.v14.i7.238]
Corresponding Author of This Article
Som P Singh, Academic Research, Department of Internal Medicine, University of Missouri Kansas City School of Medicine, 2411 Holmes Street, Kansas City, MO 64106, United States. somsingh@mail.umkc.edu
Research Domain of This Article
Cardiac & Cardiovascular Systems
Article-Type of This Article
Systematic Reviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Radiol. Jul 28, 2022; 14(7): 238-248 Published online Jul 28, 2022. doi: 10.4329/wjr.v14.i7.238
Catheter-based renal sympathetic nerve denervation on hypertension management outcomes
Som P Singh, Kevin J Varghese, Fahad M Qureshi, Macy C Anderson, John Foxworth, Mark M Knuepfer
Som P Singh, Kevin J Varghese, Fahad M Qureshi, Macy C Anderson, John Foxworth, Department of Internal Medicine, University of Missouri Kansas City School of Medicine, Kansas City, MO 64106, United States
Mark M Knuepfer, Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, Saint Louis, MO 63104, United States
Author contributions: Singh SP, Varghese KJ, Qureshi FQ, and Knuepfer MM designed the research study; Singh SP, Varghese KJ, and Qureshi FQ performed the research; Anderson MA and Foxworth J contributed critical revision; Varghese KV and Qureshi FQ analyzed the data; and All authors wrote the manuscript. All authors have read and approve the final manuscript.
Conflict-of-interest statement: All authors report no relevant conflicts of interest for this article.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Som P Singh, Academic Research, Department of Internal Medicine, University of Missouri Kansas City School of Medicine, 2411 Holmes Street, Kansas City, MO 64106, United States. somsingh@mail.umkc.edu
Received: February 14, 2022 Peer-review started: February 14, 2022 First decision: April 8, 2022 Revised: May 6, 2022 Accepted: July 5, 2022 Article in press: July 5, 2022 Published online: July 28, 2022
ARTICLE HIGHLIGHTS
Research background
The background behind this literature is the initial collaboration between SPS and MMK who explored the effects of renal afferent denervation from a basic science perspective. Of note, MMK has contributed to a number of early literatures regarding renal sympathetic denervation.
Research motivation
The utilization of thermal radiofrequency ablation in medical practice has grown tremendously over the past decade alone. We are motivated to contribute to the potential direction of bringing this therapeutic modality to greater avenues of evaluation compared to the past. Of note, renal sympathetic denervation (RSD) is not used in the United States yet.
Research objectives
The objective was to utilize current peer-reviewed case report data to gain a current understanding of the climate regarding RSD interventions.
Research methods
Systematic Review of the literature.
Research results
RSD intervention has shown, in these case reports, to mainly lower office systolic blood pressure and lessen the patient burden on medication regimens.
Research conclusions
The promising results of RSD can simplify therapeutic regimens in patients with resistant hypertension. There is a significant amount of area which can be explored in clinical trials in the future.
Research perspectives
The study team believes this therapeutic intervention needs to be brought under greater attention among the interventional radiology community for it future usage.
