Revised: July 27, 2026
Accepted: August 17, 2026
Published online: September 28, 2026
Processing time: 117 Days and 19 Hours
Cervical cancer remains one of the leading causes of cancer-related mortality among women worldwide. Although californium-252 (252Cf) neutron brachytherapy has demonstrated favorable therapeutic efficacy for locally advanced cervical cancer, substantial inter-patient heterogeneity in treatment response still exists. Therefore, developing a reliable non-invasive predictive model before treatment is of considerable clinical importance.
To develop and validate a predictive model that integrates multiparametric mag
A total of 100 cervical cancer patients who underwent the aforementioned treatment at our institution from January 2020 to June 2025 were retrospectively enrolled. All patients underwent pretreatment multi-sequence MRI scans [T1-weighted imaging, T2-weighted imaging, dynamic contrast enhanced (DCE)-MRI, and diffusion weighted imaging (DWI)]. Based on DCE-MRI and DWI parameter maps, a k-means clustering algorithm was employed to delineate the tumor habitat atlas, partitioning the tumor into three functional subregions (H1: High vascularity/high cellularity; H2: Low vascularity/high cellularity; H3: Low vascularity/low cellularity). Radiomics features were extracted from both the whole tumor region and each habitat subregion, while deep learning features were extracted using a pre-trained ResNet50 network. The aforementioned features, along with clinical-dosimetric parameters, were fused. Following feature selection via the least absolute shrinkage and selection operator, a fusion prediction model was constructed using a support vector machine. The dataset was split into a training set (n = 70) and a validation set (n = 30) at a 7:3 ratio for model evaluation.
Habitat analysis successfully identified three types of functional subregions, whose distribution was significantly associated with tumor heterogeneity. The fusion model (Model-Fusion) achieved an area under curve (AUC) of 0.892 (95% confidence interval: 0.821-0.963) and an accuracy of 0.867 in the validation set, significantly outperforming the model based solely on clinical features (AUC = 0.712), the whole-tumor radiomics model (AUC = 0.783), and the radiomics combined with deep learning model (AUC = 0.835) (all P < 0.05). Decision curve analysis demonstrated that the fusion model provided the highest clinical net benefit. The 3-year overall survival rate was significantly higher in the model-predicted high-benefit group (92.5%) compared to the low-benefit group (71.4%, P = 0.003).
This study integrates MRI habitat atlas analysis with deep learning and radiomics. The constructed multimodal fusion model can non-invasively and accurately predict the efficacy of 252Cf neutron therapy for cervical cancer, providing a promising approach for individualized precision radiotherapy decision-making.
Core Tip: The present study developed a multimodal fusion predictive model integrating MRI habitat atlas, deep learning, and radiomics to fill the current gap in early and non-invasive prediction of treatment efficacy of californium-252 (252Cf) neutron therapy for cervical cancer, thereby provide decisive evidence and a powerful imaging tool for individualized precision radiotherapy decision-making.