Coronary physiology assessment in the catheterization laboratory

Table 1 Substances used in the catheterization laboratory for coronary vascular function assessment

Substance	Doses	Site of action	Endothelium response	Effect
Adenosine	Iv: 140 μg/kg per minute Ic: 20-150 μg bolus	Microvascular	Independent	Direct vasodilation
Acetylcholine	Ic: 10-6 M/10-5 M/ 10-4 M	Micro and macrovascular	Dependent	Vasodilation if normal endothelial function; vasoconstriction if endothelial dysfunction
Nitroglycerin	Ic: 200 μg bolus	Macrovascular	Independent	Vasodilation
Nitroprusside	Ic 0.3-0.9 μg/kg bolus	Micro and macrovascular	Independent	Vasodilation
Papaverine	Ic: 8-20 mg bolus	Micro and macrovascular	Independent	Enzyme Phosphodiesterase inhibition Vasodilation
Regadenoson	Iv: 400 μg bolus	Microvascular	Independent	Adenosine receptor agonist vasodilation