Copyright ©The Author(s) 2015.
World J Cardiol. Feb 26, 2015; 7(2): 52-64
Published online Feb 26, 2015. doi: 10.4330/wjc.v7.i2.52
Table 2 Summary of physical training protocols and outcomes in selected animal studies
Ref.Type of exerciseExercise intensityExercise durationExercise frequencyTraining periodAssessmentOutcome
Hashimoto et al[76] 2004Treadmill running10 m/min60 min5 d/wk6 wkMyosin heavy chain isoforms, cardiac wall measurementsExercise training resulted in a significant increase of α-MHC expression in both anterior and posterior wall, ensuring a beneficial role in the remodeling of the heart
Xu et al[35] 2008Treadmill running16 m/min @ 5% grade50 min5 d/wk8 wkTIMP-1, AT1, ACE, collagen volume fraction, MMPEarly exercise training after MI reduces TIMP-1 expression, improves the balance between MMPs and TIMPs, and mitigates the expressions of ACE and AT1 receptor, thus attenuating myocardial fibrosis and preserving cardiac function
De Waard et al[59] 2007Voluntary treadmill exercise trainingN/AN/A5 d/wk8 wkLV fractional shortening, Ca2+ sensitivity, PLB, SERCAVoluntary exercise improved LV and cardiomyocyte shortening, attenuates global LV dysfunction
Wan et al[34] 2007Treadmill running16 m/min @ 5% grade50 min5 d/wk8 wkEcho and RAASExercise training improved cardiac function and attenuated RAAS. Early and late exercise training had similar beneficial results
Xu et al[106] 2010Treadmill running16 m/min @ 5% grade50 min5 d/wk8 wkSOD, GPx, MnSODExercise training combined with AngII receptor blockade reduced oxidative stress
Yengo et al[147] 2012Treadmill running15% grade, speed increased from 13 to 24 m/minProgressively increased to 60 min6 d/wk10 wkCollagen concentration, non-reducible collagen cross-linking in the RVExercise training normalized the observed increase in cross-linking, and favorably modifies heart extracellular matrix