Copyright
©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Cardiol. Feb 26, 2016; 8(2): 163-179
Published online Feb 26, 2016. doi: 10.4330/wjc.v8.i2.163
Published online Feb 26, 2016. doi: 10.4330/wjc.v8.i2.163
Micromanaging cardiac regeneration: Targeted delivery of microRNAs for cardiac repair and regeneration
Jan AAM Kamps, Endothelial Biomedicine and Vascular Drug Targeting, Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, 9713GZ Groningen, The Netherlands
Guido Krenning, Cardiovascular Regenerative Medicine, Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, 9713GZ Groningen, The Netherlands
Author contributions: Both authors equally contributed to this paper with conception and design of the study, literature review and analysis, drafting and critical revision and editing, and final approval of the final version.
Conflict-of-interest statement: No potential conflicts of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Guido Krenning, PhD, Cardiovascular Regenerative Medicine, Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Hanzeplein 1 (EA11), 9713GZ Groningen, The Netherlands. g.krenning@umcg.nl
Telephone: +31-50-2615181 Fax: +31-50-3619911
Received: July 30, 2015
Peer-review started: July 31, 2015
First decision: September 28, 2015
Revised: October 9, 2015
Accepted: January 5, 2016
Article in press: January 7, 2016
Published online: February 26, 2016
Peer-review started: July 31, 2015
First decision: September 28, 2015
Revised: October 9, 2015
Accepted: January 5, 2016
Article in press: January 7, 2016
Published online: February 26, 2016
Core Tip
Core tip: Cardiac fibroblast reprogramming into cardiomyocytes holds great promise for future cardiac regenerative medicine therapies. Here, we discuss current advances in the state-of-the-art protocols for the direct reprogramming of cardiac fibroblasts into de novo cardiomyocytes in vitro and in vivo with an emphasis on microRNA-mediated reprogramming. Additionally, we discuss current advances on the state-of-the-art targeted drug delivery systems that can be employed to deliver these microRNAs to the damaged cardiac tissue.