Copyright
©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Genetics of coronary artery disease and myocardial infarction
Xuming Dai, Szymon Wiernek, Marschall S Runge, Division of Cardiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States
James P Evans, Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States
Author contributions: Dai X wrote the manuscript; Wiernek S collected the literature and generated the up-to-date chromosomal map; Evans JP and Runge MS extensively edited the manuscript.
Supported by NC TraCS to Dai X, No. 550KR91403; NIH T32 to Wiernek S, No. HL083828-04.
Conflict-of-interest statement: The authors declare no conflict of interests for this article.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Xuming Dai, MD, PhD, Division of Cardiology, University of North Carolina at Chapel Hill, 160 Dental Circle, CB # 7075, Chapel Hill, NC 27599, United States. xmdai3@med.unc.edu
Telephone: +1-919-9666965 Fax: +1-919-9664366
Received: May 3, 2015
Peer-review started: May 3, 2015
First decision: August 4, 2015
Revised: October 18, 2015
Accepted: November 10, 2015
Article in press: November 11, 2015
Published online: January 26, 2016
Peer-review started: May 3, 2015
First decision: August 4, 2015
Revised: October 18, 2015
Accepted: November 10, 2015
Article in press: November 11, 2015
Published online: January 26, 2016
Core Tip
Core tip: This review provides the most comprehensive summary of the genetics of coronary artery disease (CAD) and myocardial infarction (MI) research with a complete, up-to-date chromosomal map of all CAD and MI-susceptible genes. We discuss the existence and significance of protective genetic factors against atherosclerosis, CAD and MI. We also summarize the current status of constructing genetic risk scores to predict long-term risks of developing CAD and MI. In-stent restenosis is a new challenge in cardiology. The genetics of in-stent restenosis are also discussed in this article.