Mahmood MM, Watt J, Ahmed JM. Thrombus aspiration during primary percutaneous coronary intervention for acute myocardial infarction: A review of clinical evidence and guidelines. World J Cardiol 2015; 7(12): 889-894 [PMID: 26730294 DOI: 10.4330/wjc.v7.i12.889]
Corresponding Author of This Article
Dr. Javed M Ahmed, Consultant Cardiologist, Cardiology Department, Freeman Hospital, Freeman Road, Newcastle-upon-Tyne NE7 7DN, United Kingdom. javed.ahmed@nuth.nhs.uk
Research Domain of This Article
Cardiac & Cardiovascular Systems
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Cardiol. Dec 26, 2015; 7(12): 889-894 Published online Dec 26, 2015. doi: 10.4330/wjc.v7.i12.889
Thrombus aspiration during primary percutaneous coronary intervention for acute myocardial infarction: A review of clinical evidence and guidelines
Muhammad Muzaffar Mahmood, Jonathan Watt, Javed M Ahmed
Muhammad Muzaffar Mahmood, Jonathan Watt, Javed M Ahmed, Cardiology Department, Freeman Hospital, Newcastle-upon-Tyne NE7 7DN, United Kingdom
Author contributions: Mahmood MM performed the search and wrote the initial draft; Watt J and Ahmed JM reviewed the article and Ahmed JM is the guarantor of the content.
Conflict-of-interest statement: The authors have no conflict of interest to declare.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Javed M Ahmed, Consultant Cardiologist, Cardiology Department, Freeman Hospital, Freeman Road, Newcastle-upon-Tyne NE7 7DN, United Kingdom. javed.ahmed@nuth.nhs.uk
Telephone: +44-191-2137145 Fax: +44-191-2231175
Received: May 28, 2015 Peer-review started: June 1, 2015 First decision: June 18, 2015 Revised: October 4, 2015 Accepted: October 20, 2015 Article in press: October 27, 2015 Published online: December 26, 2015
Core Tip
Core tip: The role of manual thrombus aspiration during primary percutaneous coronary intervention (PPCI) for acute ST segment elevation myocardial infarction (STEMI) has been a matter of significant research and intense debate recently. The rationale for manual thrombus aspiration during PPCI is the removal of intracoronary thrombus, thus avoiding the complication of downstream embolization leading to impaired myocardial perfusion. In this review article, we present the data from early clinical trials and meta-analyses of thrombus aspiration during PPCI, and the more recent evidence from larger multi-center randomized controlled trials that have had a major influence on clinical practice. We highlight the relevant major society guidelines for thrombus aspiration during PPCI and provide the reader with an overview of this technology and its role in contemporary management of STEMI.
