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©2014 Baishideng Publishing Group Inc. All rights reserved.
World J Cardiol. Jun 26, 2014; 6(6): 478-494
Published online Jun 26, 2014. doi: 10.4330/wjc.v6.i6.478
Published online Jun 26, 2014. doi: 10.4330/wjc.v6.i6.478
Cardiomyopathies: Evolution of pathogenesis concepts and potential for new therapies
Hamayak Sisakian, Department Cardiology, Clinic of General and Invasive Cardiology, University Hospital 1, Yerevan State Medical University, Yerevan 0025, Armenia
Author contributions: Sisakian H solely contributed to this paper.
Correspondence to: Hamayak Sisakian, Professor, Department Cardiology, Clinic of General and Invasive Cardiology, University Hospital 1, Yerevan State Medical University, 2 Koryun street, Yerevan 0025, Armenia. hamayak_sisakyan@hotmail.com
Telephone: +374-10-582023 Fax: +374-10-541350
Received: January 9, 2013
Revised: March 6, 2014
Accepted: March 13, 2014
Published online: June 26, 2014
Revised: March 6, 2014
Accepted: March 13, 2014
Published online: June 26, 2014
Core Tip
Core tip: Cardiomyopathies represent a different group of disorders in which myocardium is itself structurally and functionally abnormal. During recent decades, the genetics, pathophysiology and diagnosis of cardiomypathy have advanced from the traditional methods of clinical presentation to new genetic and imaging techniques. Nevertheless, the differences in definition, classification, pathophysiological mechanisms and diagnosis are controversial issues in clinical practice. The purpose of this review is to present the current state of classification, genetics, diagnostic approaches and management in order to provide useful instructions for clinical practice.