Copyright
©2014 Baishideng Publishing Group Co., Limited. All rights reserved.
World J Cardiol. Apr 26, 2014; 6(4): 154-174
Published online Apr 26, 2014. doi: 10.4330/wjc.v6.i4.154
Published online Apr 26, 2014. doi: 10.4330/wjc.v6.i4.154
Arrhythmogenic ventricular cardiomyopathy: A paradigm shift from right to biventricular disease
Ardan M Saguner, Corinna Brunckhorst, Firat Duru, Department of Cardiology, University Heart Center, CH-8091 Zurich, Switzerland
Author contributions: Saguner AM, Brunckhorst C and Duru F equally contributed to this article.
Supported by The Georg and Bertha Schwyzer-Winiker Foundation, Zurich, Switzerland
Correspondence to: Firat Duru, Professor, Department of Cardiology, University Heart Center, Rämistrasse 100, CH-8091 Zurich, Switzerland. firat.duru@usz.ch
Telephone: +41-44-2553565 Fax: +41-44-2554401
Received: December 17, 2013
Revised: February 25, 2014
Accepted: March 13, 2014
Published online: April 26, 2014
Revised: February 25, 2014
Accepted: March 13, 2014
Published online: April 26, 2014
Core Tip
Core tip: This manuscript constitutes an updated overview about arrhythmogenic ventricular cardiomyopathy (AVC) and describes well the paradigm shift in the understanding of AVC from an isolated right-sided entity to biventricular disease that can present with multiple facets. The most recent advances in molecular and clinical research are discussed, with particular focus on genetic novelties and risk stratification. We believe that this review will help clinicians to better understand the pathomechanisms that lead to AVC, its diagnosis and state-of-the-art therapeutic decision making.