Physiology of natriuretic peptides: The volume overload hypothesis revisited

doi:10.4330/wjc.v6.i1.4

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Jan 26, 2014 (publication date) through Jun 15, 2024

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World Journal of Cardiology

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1949-8462

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Cardiol. Jan 26, 2014; 6(1): 4-7
Published online Jan 26, 2014. doi: 10.4330/wjc.v6.i1.4

Physiology of natriuretic peptides: The volume overload hypothesis revisited

Olli Arjamaa

Olli Arjamaa, Department of Biology, University of Turku, 20014 Turku, Finland

Author contributions: Arjamaa O solely contributed to this paper.

Correspondence to: Olli Arjamaa, MD, PhD, Senior Scientist, Department of Biology, University of Turku, Vesilinnanmäki, 20014 Turku, Finland. olli.arjamaa@utu.fi

Telephone: +358-4-05125452

Received: October 7, 2013
Revised: November 29, 2013
Accepted: December 17, 2013
Published online: January 26, 2014

Core Tip

Core tip: A new concept is suggested for the understanding of the physiology of natriuretic peptides. Both chemical and physical challenges will ultimately increase the oxygen consumption of the heart which is the factor regulating the release of natriuretic peptides. Diuresis, natriuresis and plasma shift lead to hemoconcentration and the oxygen transport in human body will be enhanced.