Berberine behind the thriller of marked symptomatic bradycardia

doi:10.4330/wjc.v5.i7.261

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World Journal of Cardiology

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1949-8462

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World J Cardiol. Jul 26, 2013; 5(7): 261-264
Published online Jul 26, 2013. doi: 10.4330/wjc.v5.i7.261

Berberine behind the thriller of marked symptomatic bradycardia

Margherita Cannillo, Simone Frea, Cristina Fornengo, Elisabetta Toso, Giancarlo Mercurio, Stefania Battista, Fiorenzo Gaita

Margherita Cannillo, Simone Frea, Cristina Fornengo, Elisabetta Toso, Fiorenzo Gaita, Division of Cardiology, Cardiovascular Department, AOU S. Giovanni Battista di Torino and University of Torino, 10100 Torino, Italy

Giancarlo Mercurio, Stefania Battista, Emergency Department, AOU S. Giovanni Battista di Torino and University of Torino, 10100 Torino, Italy

Author contributions: Cannillo M and Frea S designed the report and wrote the paper; Fornengo C, Frea S, Toso E, Mercurio G and Battista S were attending doctors for the patients; Cannillo M and Toso E performed ergometric stress test and ECG Holter; Toso E and Gaita F approved the final version to be published.

Correspondence to: Margherita Cannillo, MD, Division of Cardiology, Cardiovascular Department, AOU S. Giovanni Battista di Torino and University of Torino, Corso Bramante 88, 10100 Turino, Italy. margheritacannillo@gmail.com.

Telephone: +39-11-6335571 Fax: +39-11-6335572

Received: April 23, 2013
Revised: June 7, 2013
Accepted: June 18, 2013
Published online: July 26, 2013

Core Tip

Core tip: Berberine is widely used in traditional Chinese medicine for the treatment of congestive heart failure, hypertension, diabetes, and dyslipidaemia. We report a case of marked symptomatic sinus bradycardia with competitive junctional rhythm caused by berberine, showing that berberine, due to its antiarrhythmic properties, can cause the onset of bradyarrhythmia. In this case report, we focus on the possible side effects of so-called natural medicine based on holistic, home, and herbal remedies, which is considered to be safe only because the treatment is natural. However, under certain conditions, natural medicine can lead to potential health risks in patients.