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World J Cardiol. Nov 26, 2026; 18(11): 126752
Published online Nov 26, 2026. doi: 10.4330/wjc.126752
Published online Nov 26, 2026. doi: 10.4330/wjc.126752
Role of novel inflammatory indices in predicting major adverse cardiovascular events following revascularization in chronic limb-threatening ischemia
Abeer A Alwahadneh, Dania A Bani Hani, Faculty of Nursing, Middle East University, Amman 11941, Jordan
Jafar A Alshraideh, Kawther Al-Hadidi, Department of Clinical Nursing, University of Jordan, Amman 11942, Jordan
Mohammad S Abdallah, RMS, Jordan Royal Medical Services, Amman 11942, Jordan
Bayan Alshraideh, Dentistry School, University of Jordan, Amman 11942, Jordan
Khalil Yousef, School of Humanities, Social Sciences and Health, University of Wollongong in Dubai, Dubai 20183, United Arab Emirates
Khalil Yousef, School of Nursing, University of Jordan, Amman 11942, Jordan
Author contributions: Alwahadneh AA and Alshraideh JA conceived the project; Alwahadneh AA, Hani DAB and Abdallah MS were involved in data collection; Abdallah MS, Alshraideh B and Alwahadneh AA were responsible for data organization and curation; Alwahadneh AA, Al-Hadidi K, and Hani DAB performed the statistical analysis; Alshraideh B, Hani DAB and Abdallah MS performed literature search; Alwahadneh AA, Hani DAB and Abdallah MS prepared the first draft; Yousef K and Alshraideh JA critically reviewed the manuscript; Alshraideh JA, Yousef K, Alwahadneh AA approved the final version; Alshraideh JA performed the journal search and submitted the initial version to journal.
AI contribution statement: AI tools, specifically (Grammarly), were used solely for language polishing and formatting assistance. No AI tool was used to generate research data, interpret results, or formulate conclusions. All AI-assisted content was critically reviewed and revised by the authors, who take full responsibility for the accuracy, originality, and integrity of the manuscript.
Institutional review board statement: This study was approved by the Institutional Review Board at the Ministry of Health (approval No. MOH/REC/2024/284) and Royal Medical Services (approval No. 9/2024). The research was conducted in full accordance with the World Medical Association International Code of Medical Ethics and the Declaration of Helsinki.
Informed consent statement: Participation was voluntary, and verbal informed consent was obtained from all participants before inclusion.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Data sharing statement: Data is available with the corresponding author and can be shared on request.
Corresponding author: Jafar A Alshraideh, PhD, Professor, Department of Clinical Nursing, University of Jordan, Amman 11942, Jordan. jalasad@ju.edu.jo
Received: August 12, 2026
Revised: September 1, 2026
Accepted: October 26, 2026
Published online: November 26, 2026
Processing time: 92 Days and 19.9 Hours
Revised: September 1, 2026
Accepted: October 26, 2026
Published online: November 26, 2026
Processing time: 92 Days and 19.9 Hours
Core Tip
Core Tip: In this prospective multicenter cohort of patients with chronic limb-threatening ischemia undergoing lower-limb revascularization, Systemic Inflammatory Response Index (SIRI) was independently associated with six-month major adverse cardiovascular events and improved the discriminatory performance of a multivariable clinical model. Bootstrap internal validation demonstrated that the model retained strong discriminatory ability after correction for optimism. These findings highlight the potential of SIRI to refine cardiovascular risk assessment in this high-risk population, while external validation in independent cohorts remains essential before clinical implementation.