Coenzyme Q10 for heart failure and symptomatic cardiovascular diseases

doi:10.4330/wjc.126612

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World Journal of Cardiology

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1949-8462

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Cardiol. Nov 26, 2026; 18(11): 126612
Published online Nov 26, 2026. doi: 10.4330/wjc.126612

Coenzyme Q10 for heart failure and symptomatic cardiovascular diseases

Yen-Chen Lin, Wei-Chieh Huang, Chun-Tsai Tsai, Kai-Ti Yang, Yun-Chen Chang, Yen-Po Lin, Wei-Chun Huang, Gen-Min Lin

Yen-Chen Lin, Department of Medicine, Linkou Chang Gung Memorial Hospital, Taoyuan 333, Taiwan

Wei-Chieh Huang, Department of Internal Medicine, Taipei Veterans General Hospital, Taipei 112, Taiwan

Chun-Tsai Tsai, Cardiovascular Center, Taipei Veterans General Hospital, Taipei 112, Taiwan

Kai-Ti Yang, Department of Cardiovascular Surgery, Landseed International Hospital, Taoyuan 324, Taiwan

Yun-Chen Chang, School of Nursing and Graduate Institute of Nursing, China Medical University, Taichung 406, Taiwan

Yen-Po Lin, Critical Care Medicine, Taipei Tzu Chi General Hospital, New Taipei 23142, Taiwan

Wei-Chun Huang, Cardiovascular Center, Kaohsiung Veterans General Hospital, Kaohsiung 81346, Taiwan

Gen-Min Lin, Department of Medicine, Hualien Armed Forces General Hospital, Hualien 970, Taiwan

Author contributions: Lin YC and Lin GM performed the literature search procedure; Huang WC, Tsai CT, Yang KT made the Tables; Chang YC, Lin YP, and Huang WC made the Figures; Lin GM edited the manuscript. All authors contributed to the discussion and provided critical comments on the manuscript.

AI contribution statement: Portions of this manuscript were edited using AI tools solely for language refinement (Gemini pro) and for Figures 1 and 2 generation (Gemini pro). The authors carefully reviewed and verified all AI-assisted outputs and take full responsibility for the scientific content of the manuscript.

Supported by Hualien Armed Forces General Hospital, Taiwan, No. HAFGH-D-115004.

Conflict-of-interest statement: The authors declare that they have no conflict of interest.

Corresponding author: Gen-Min Lin, Director, FACC, FAHA, FESC, Department of Medicine, Hualien Armed Forces General Hospital, No. 100 Jinfeng Street, Hualien 970, Taiwan. farmer507@yahoo.com.tw

Received: August 10, 2026
Revised: September 4, 2026
Accepted: October 28, 2026
Published online: November 26, 2026
Processing time: 99 Days and 15.6 Hours

Core Tip

Core Tip: Coenzyme Q10 (CoQ10) plays a dual role in cardiomyocyte bioenergetics and antioxidant defense. In heart failure (HF) and ischemic heart disease, CoQ10 deficiency exacerbates energy starvation and oxidative stress. Evidence from trials like Q-SYMBIO underscores its ability to reduce mortality and hospitalizations in patients with HF with reduced ejection fraction. Additionally, CoQ10 mitigates statin-induced myopathy and cardiomyopathy. Emerging applications in microvascular angina and HF with preserved ejection fraction represent promising frontiers requiring further clinical evaluation.