Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.
World J Cardiol. Nov 26, 2026; 18(11): 125738
Published online Nov 26, 2026. doi: 10.4330/wjc.125738
Published online Nov 26, 2026. doi: 10.4330/wjc.125738
Factors associated with one-year mortality in patients with hyponatremia hospitalized in a cardiology department: An exploratory retrospective cohort study
Kristina G Pereverzeva, Sergey S Yakushin, Yulia O Cherkasova, Tatiana A Korchagina, Dmitry A Kuznetsov, Department of Hospital Therapy with a Course in Medical and Social Expertise, Federal State Budgetary Educational Institution of Higher Education I.P. Pavlov Ryazan State Medical University of the Ministry of Health of the Russian Federation, Ryazan 390026, Ryazanskaya Oblast’, Russia
Author contributions: Pereverzeva KG and Yakushin SS contributed to the study conceptualization and project administration; Pereverzeva KG was responsible for the methodology, data curation, drafting of the original manuscript, and editing of subsequent versions; Yakushin SS provided critical resources and reviewed the manuscript; Cherkasova YO, Korchagina TA, and Kuznetsov DA performed patient enrollment, acquisition of clinical data, and collection of the study material. All authors approved the final version for publication.
AI contribution statement: DeepSeek (version V3, 2025) was used for language editing and translation of the manuscript.
Institutional review board statement: This study was approved by the Local Ethics Committee of Ryazan State Medical University, No. 7.
Informed consent statement: Upon hospitalization, all patients signed a general informed consent form for medical care. For this study, all data were de-identified prior to analysis. The Institutional Review Board approved the study and granted a waiver of additional informed consent, as the study involved no direct patient contact and used only routinely collected clinical data from medical records and electronic registries.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Data sharing statement: The statistical code used for the analyses and the datasets analyzed during the current study can be obtained from the corresponding author upon reasonable request.
Corresponding author: Sergey S Yakushin, Professor, Department of Hospital Therapy with a Course in Medical and Social Expertise, Federal State Budgetary Educational Institution of Higher Education I.P. Pavlov Ryazan State Medical University of the Ministry of Health of the Russian Federation, No. 96 Stroykova Street, Ryazan 390026, Ryazanskaya Oblast’, Russia.
Received: July 17, 2026
Revised: September 13, 2026
Accepted: November 2, 2026
Published online: November 26, 2026
Processing time: 123 Days and 17.4 Hours
Revised: September 13, 2026
Accepted: November 2, 2026
Published online: November 26, 2026
Processing time: 123 Days and 17.4 Hours
Core Tip
Core Tip: Hyponatremia in cardiac inpatients is associated with high one-year mortality (44.5%). In this exploratory analysis, factors associated with one-year mortality included stage II chronic heart failure, lower minimum sodium, and elevated creatine kinase-MB activity. However, the association with minimum sodium was not confirmed in sensitivity analyses, whereas creatine kinase-MB and stage II chronic heart failure remained significant in the Firth’s penalized model. These findings are hypothesis-generating and require prospective validation.