Minireview of relationship between perfluoroalkyl and polyfluoroalkyl substances and hypertension

doi:10.4330/wjc.125866

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World Journal of Cardiology

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1949-8462

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Minireviews

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Cardiol. Oct 26, 2026; 18(10): 125866
Published online Oct 26, 2026. doi: 10.4330/wjc.125866

Minireview of relationship between perfluoroalkyl and polyfluoroalkyl substances and hypertension

Jie Li, Liang Chen

Jie Li, Department of Cardiology, Ruijin-Hainan Hospital, Shanghai Jiao Tong University School of Medicine (Hainan Boao Research Hospital), Qionghai 571400, Hainan Province, China

Jie Li, Liang Chen, Department of Cardiology, The Second Affiliated Hospital of Dalian Medical University, Dalian 112000, Liaoning Province, China

Author contributions: Li J investigated the current research status and drafted the article; Chen L revised the article critically for important intellectual content.

AI contribution statement: AI tool of Doubao was used solely for generation of Figures. No AI tool was used to generate research data, interpret results, or formulate conclusions. All AI-assisted content was critically reviewed and revised by the authors, who take full responsibility for the accuracy, originality, and integrity of the manuscript.

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

Corresponding author: Liang Chen, PhD, Chief Physician, Professor, Department of Cardiology, The Second Affiliated Hospital of Dalian Medical University, Zhongshan Road, Dalian 112000, Liaoning Province, China. dyeyarrhythmia@163.com

Received: July 20, 2026
Revised: August 19, 2026
Accepted: October 9, 2026
Published online: October 26, 2026
Processing time: 96 Days and 23.8 Hours

Core Tip

Core Tip: This article systematically summarizes current evidence on the association between perfluoroalkyl and polyfluoroalkyl substances exposure and hypertension, highlighting that most studies support a positive correlation. We elucidate the potential biological mechanisms, including nuclear receptor activation, oxidative stress, impaired renal sodium handling, and thyroid hormone disruption. Given the controversies and racial/regional research gaps, future studies should encompass diverse populations and broader polyfluoroalkyl substances types.