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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Cardiol. Aug 26, 2025; 17(8): 109903
Published online Aug 26, 2025. doi: 10.4330/wjc.v17.i8.109903
Published online Aug 26, 2025. doi: 10.4330/wjc.v17.i8.109903
Effect of extracorporeal membrane oxygenation combined with hemoperfusion on inflammatory factors in patients with cardiogenic shock
Jing-Yan Hao, Qin Yang, Wen-Hua Lin, Department of Cardiology, TEDA International Cardiovascular Hospital, Tianjin 300457, China
Shi-Fu Wang, Wei Wang, Shan Guo, Intensive Care Unit, TEDA International Cardiovascular Hospital, Tianjin 300450, China
Zhuo-Xian Zhao, Ying Zhou, Fei Dong, Cardiac Care Unit, TEDA International Cardiovascular Hospital, Tianjin 300457, China
Author contributions: Hao JY contributed to study design, data collection, initial manuscript writing; Wang SF and Yang Q contributed to research methodology design, technical support; Wang W and Zhao ZX contributed to data analysis and statistical processing; Guo S and Zhou Y contributed to data validation, figure and table preparation; Dong F contributed to study supervision and project coordination; Lin WH contributed to research guidance, funding acquisition and manuscript review.
Supported by the Priority Project of the Multi-Source Investment Fund Program, China, No. S21DYZD3172; and the Tianjin Key Medical Discipline (Specialty) Construction Project, China, No. TJYXZDXK-020A.
Institutional review board statement: This study was approved by the Ethics Committee of TEDA International Cardiovascular Hospital (Ethics Approval No.: 2022K034). It was conducted in accordance with the principles of the Declaration of Helsinki, and written informed consent was obtained from all patients or their legal guardians.
Informed consent statement: Due to the anonymization of all patient data, no additional consent for publication is required.
Conflict-of-interest statement: All authors declare no financial or non-financial competing interests.
Data sharing statement: The data generated in this study are stored in the TEDA International Cardiovascular Hospital ECMO Registry (Registration No.: 2022-034). Anonymized data may be requested from the corresponding author upon reasonable request.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Wen-Hua Lin, PhD, Chief Physician, Department of Cardiology, TEDA International Cardiovascular Hospital, 3rd Street, Tianjin Economic-Technological Deve
Received: May 27, 2025
Revised: June 15, 2025
Accepted: July 22, 2025
Published online: August 26, 2025
Processing time: 88 Days and 14.2 Hours
Revised: June 15, 2025
Accepted: July 22, 2025
Published online: August 26, 2025
Processing time: 88 Days and 14.2 Hours
Core Tip
Core Tip: This study evaluates the efficacy of adsorptive extracorporeal membrane oxygenation (ECMO) (ECMO combined with HA380 hemoperfusion column) in reducing inflammatory burden in cardiogenic shock patients. Our single-center retrospective study (n = 78) demonstrates that adsorptive ECMO efficiently clears pro-inflammatory cytokines (interleukin-6: 94.4% reduction at 72 hours; tumour necrosis factor alpha: 70.1% reduction) and improves hemodynamics, including shorter ECMO duration (114 vs 141 hours, P = 0.046) and higher weaning success rate (66.7% vs 38.5%, P = 0.013).