Role of hydrogen peroxide preconditioning in mesenchymal stem cell-mediated heart regeneration: Molecular insights

doi:10.4330/wjc.v17.i8.107437

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Aug 26, 2025 (publication date) through Aug 21, 2025

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World Journal of Cardiology

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1949-8462

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Cardiol. Aug 26, 2025; 17(8): 107437
Published online Aug 26, 2025. doi: 10.4330/wjc.v17.i8.107437

Role of hydrogen peroxide preconditioning in mesenchymal stem cell-mediated heart regeneration: Molecular insights

Anum Siraj, Kanwal Haneef

Anum Siraj, Kanwal Haneef, Dr. Zafar H. Zaidi Center for Proteomics, University of Karachi, Karachi 75270, Sindh, Pakistan

Author contributions: Siraj A conducted the literature review and completed the first draft of the paper; Haneef K conceived the idea, provided detailed guidance, and finalized the paper; all of the authors read and approved the final version of the manuscript to be published.

Conflict-of-interest statement: The authors declare no conflict of interests for this article.

Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Kanwal Haneef, PhD, Assistant Professor, Dr. Zafar H. Zaidi Center for Proteomics, University of Karachi, University Road, Karachi 75270, Sindh, Pakistan. k.haneef@uok.edu.pk

Received: March 25, 2025
Revised: May 22, 2025
Accepted: August 1, 2025
Published online: August 26, 2025
Processing time: 149 Days and 21.1 Hours

Core Tip

Core Tip: Hydrogen peroxide (H₂O₂) preconditioning is reported to increase protective mechanisms in mesenchymal stem cells and enhance their ability to regenerate in damaged hearts. However, its molecular mechanism remains under-explored. This review highlights the studies on the protective biological functions and regulatory mechanisms associated with H₂O₂ preconditioning in heart regeneration. Moreover, the role of the H₂O₂-activated redox-sensitive transcription factors and their associated pathways in cell survival, proliferation, migration, paracrine effect, and cardiac differentiation is discussed. The molecular insights provided in this review will possibly help in the development of cardiovascular regenerative therapy.