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World J Cardiol. Jan 26, 2024; 16(1): 10-15
Published online Jan 26, 2024. doi: 10.4330/wjc.v16.i1.10
Unveiling the silent link: Normal-tension glaucoma's enigmatic bond with cardiac blood flow
Prasanna Venkatesh Ramesh, Arvind Kumar Morya, Ajanya K Aradhya, Pavithra Pannerselvam, Sai Thaejesvi Gopalakrishnan, Shruthy Vaishali Ramesh, Aji Kunnath Devadas, Navaneeth Krishna
Prasanna Venkatesh Ramesh, Department of Glaucoma and Research, Mahathma Eye Hospital Private Limited, Trichy 620017, Tamil Nadu, India
Arvind Kumar Morya, Department of Ophthalmology, All India Institute of Medical Sciences, Hyderabad 508126, Telangana, India
Ajanya K Aradhya, Aji Kunnath Devadas, Navaneeth Krishna, Department of Optometry and Visual Science, Mahathma Eye Hospital Private Limited, Trichy 620017, Tamil Nadu, India
Pavithra Pannerselvam, Sai Thaejesvi Gopalakrishnan, Mahathma Eye Hospital Private Limited, Trichy 620017, Tamil Nadu, India
Shruthy Vaishali Ramesh, Department of Cataract and Refractive Surgery, Mahathma Eye Hospital Private Limited, Trichy 620017, Tamil Nadu, India
Author contributions: Ramesh PV and Morya AK contributed to the design and implementation of the research, the analysis of the results, conducted data analysis; Aradhya AK designed the research study and and process of writing the manuscripts; Ramesh SV contributed to conceptualization and incorporated suggestions; Pannerselvam P and Gopalakrishnan ST played pivotal roles in validating the data; Devdas AK and Krishna N offered their expertise in reviewing and editing the manuscript; All authors have read and approved the final manuscript.
Conflict-of-interest statement: There are no conflicts of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Prasanna Venkatesh Ramesh, MBBS, MS, DNB, Department of Glaucoma and Research, Mahathma Eye Hospital Private Limited, No. 6 Seshapuram, Tennur, Trichy - 620017, Tamil Nadu, India. email2prajann@gmail.com
Received: November 22, 2023
Peer-review started: November 22, 2023
First decision: November 30, 2023
Revised: December 14, 2023
Accepted: January 3, 2024
Article in press: January 3, 2024
Published online: January 26, 2024
Core Tip

Core Tip: Cardiovascular disease and glaucoma may appear unrelated at first glance, but recent research suggests a potential link between the two seemingly distinct health issues. This review delves into the complex interplay of vascular dysregulation, blood pressure, perfusion pressure, neurovascular coupling, and oxidative stress. Furthermore, certain medications frequently prescribed for managing cardiovascular disease and high blood pressure, such as beta-blockers, may influence blood flow to the eyes. This, in turn, could potentially increase the risk of glaucoma in some individuals. This research highlights how cardiac dynamics can impact ocular health, even when intraocular pressure remains within the normal range.