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©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Cardiol. Apr 26, 2021; 13(4): 82-94
Published online Apr 26, 2021. doi: 10.4330/wjc.v13.i4.82
Published online Apr 26, 2021. doi: 10.4330/wjc.v13.i4.82
Dabigatran, rivaroxaban, and apixaban are superior to warfarin in Asian patients with non-valvular atrial fibrillation: An updated meta-analysis
Wei-Jia Li, Paraschos Archontakis-Barakakis, Leonidas Palaiodimos, Yu-Chiang Wang, Robert Faillace, Damianos G Kokkinidis, Department of Medicine, Jacobi Medical Center, Bronx, NY 10461, United States
Dimitrios Kalaitzoglou, Department of Surgery, 424 General Army Hospital of Thessaloniki, Thessaloniki 56429, Greece
Lazaros Tzelves, Department of Urology, Sismanogleio Hospital, Athens 15126, Greece
Apostolos Manolopoulos, Clinical Research and Evidence-Based Medicine Unit, Aristotle University of Thessaloniki, Thessaloniki 54124, Greece
Stefanos Giannopoulos, Division of Cardiology, Rocky Mountain Regional VA Medical Center, Denver, CO 80045, United States
Author contributions: All listed authors have: (1) Substantial contributions to the conception and design or the acquisition, analysis, or interpretation of the data; (2) Substantial contributions to the drafting of the articles or critical revision for important intellectual content; (3) Final approval of the version to be published; and (4) Agreement to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the article are appropriately investigated and resolved.
Conflict-of-interest statement: All the authors declare no conflict of interest.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Damianos G Kokkinidis, MD, MSc, Academic Fellow, Doctor, Department of Medicine, Jacobi Medical Center, Albert Einstein College of Medicine, 1400 Pelham Parkway South, Bronx, NY 10461, United States. damiankokki@gmail.com
Received: December 8, 2020
Peer-review started: December 8, 2020
First decision: February 15, 2021
Revised: February 21, 2021
Accepted: April 13, 2021
Article in press: April 13, 2021
Published online: April 26, 2021
Peer-review started: December 8, 2020
First decision: February 15, 2021
Revised: February 21, 2021
Accepted: April 13, 2021
Article in press: April 13, 2021
Published online: April 26, 2021
Core Tip
Core Tip: Dabigatran, rivaroxaban, apixaban have better efficacy (reduction in ischemic stroke and all-cause mortality) and are safer (reduction in major bleeding) than warfarin. Dabigatran is associated with a lower rate of intracranial hemorrhage than warfarin, while rivaroxaban and apixaban appear to have a trend towards reduced intracranial hemorrhage, without statistical significance. Dabigatran, rivaroxaban, and apixaban are associated with a lower rate of gastrointestinal bleeding.