Retrospective Cohort Study
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Cardiol. Sep 26, 2020; 12(9): 450-459
Published online Sep 26, 2020. doi: 10.4330/wjc.v12.i9.450
Clinical significance of prolonged chest pain in vasospastic angina
Hiroki Teragawa, Chikage Oshita, Yuichi Orita
Hiroki Teragawa, Chikage Oshita, Yuichi Orita, Department of Cardiovascular Medicine, JR Hiroshima Hospital, Hiroshima 732-0057, Japan
Author contributions: Orita Y and Oshita C contributed to the acquisition of data; Teragawa H contributed to the writing and revision of the manuscript.
Institutional review board statement: This study was approved by the Institutional Review Board of Medical Corporation JR Hiroshima Hospital.
Informed consent statement: Informed consent was obtained from all of the patients.
Conflict-of-interest statement: None of the authors have any conflicts of interest to declare.
Data sharing statement: No additional data.
STROBE statement: The guidelines of the STROBE statement have been adopted.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Hiroki Teragawa, FACC, FACP, FAHA, MD, PhD, Chief Doctor, Department of Cardiovascular Medicine, JR Hiroshima Hospital, 3-1-36 Futabanosato, Higashi-ku, Hiroshima 732-0057, Japan.
Received: June 2, 2020
Peer-review started: June 28, 2020
First decision: June 15, 2020
Revised: June 28, 2020
Accepted: September 15, 2020
Article in press: September 15, 2020
Published online: September 26, 2020
Core Tip

Core Tip: We have sometimes experienced patients with vasospastic angina (VSA) who had prolonged chest symptoms (≥ 15 min). We showed that such VSA patients had higher frequencies of other serious symptoms and variant angina as well as higher frequencies of spasm induction by a low dose of acetylcholine, total occlusion due to spasm, focal spasm, and unavoidable use of nitroglycerin in the spasm provocation test (SPT). On the other hand, the frequency of chest symptoms did not influence these findings in the SPT. Prolonged chest symptoms may be related to more severe characteristics of VSA.