Published online Sep 26, 2020. doi: 10.4330/wjc.v12.i9.437
Peer-review started: February 28, 2020
First decision: May 28, 2020
Revised: June 11, 2020
Accepted: August 24, 2020
Article in press: August 24, 2020
Published online: September 26, 2020
Core Tip: A comprehensive assessment of ventricular repolarization process is an important part of electrocardiogram (ECG) diagnostics. First of all, the increased repolarization heterogeneity is associated with arrhythmogenesis. Besides, repolarization disturbances reflect the degree of electric remodeling of myocardium related to heart failure degree and mortality. We herein discuss the electrophysiological basis for repolarization heterogeneity and the factors that modulate it. We demonstrate that repolarization heterogeneity has various aspects – temporal and spatial, global and local, and there is a need in different ECG-indices to evaluate all the aspects.