Review
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Cardiol. Sep 26, 2020; 12(9): 437-449
Published online Sep 26, 2020. doi: 10.4330/wjc.v12.i9.437
Dispersion of ventricular repolarization: Temporal and spatial
Natalia V Arteyeva
Natalia V Arteyeva, Laboratory of Cardiac Physiology, Institute of Physiology of Komi Science Centre of the Ural Branch of the Russian Academy of Sciences, Syktyvkar 167982, Russia
Author contributions: Arteyeva NV analyzed the literary and own data, and wrote the paper.
Conflict-of-interest statement: Author declare no conflict of interests for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Natalia V Arteyeva, PhD, Senior Scientist, Laboratory of Cardiac Physiology, Institute of Physiology of Komi Science Centre of the Ural Branch of the Russian Academy of Sciences, 50 Pervomayskaya st, Syktyvkar 167982, Russia. natalia.arteyeva@gmail.com
Received: February 28, 2020
Peer-review started: February 28, 2020
First decision: May 28, 2020
Revised: June 11, 2020
Accepted: August 24, 2020
Article in press: August 24, 2020
Published online: September 26, 2020
Core Tip

Core Tip: A comprehensive assessment of ventricular repolarization process is an important part of electrocardiogram (ECG) diagnostics. First of all, the increased repolarization heterogeneity is associated with arrhythmogenesis. Besides, repolarization disturbances reflect the degree of electric remodeling of myocardium related to heart failure degree and mortality. We herein discuss the electrophysiological basis for repolarization heterogeneity and the factors that modulate it. We demonstrate that repolarization heterogeneity has various aspects – temporal and spatial, global and local, and there is a need in different ECG-indices to evaluate all the aspects.