Review
Copyright ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Cardiol. Oct 26, 2019; 11(10): 221-235
Published online Oct 26, 2019. doi: 10.4330/wjc.v11.i10.221
Cellular models for human cardiomyopathy: What is the best option?
Nerea Jimenez-Tellez, Steven C Greenway
Nerea Jimenez-Tellez, Department of Biochemistry & Molecular Biology, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada
Steven C Greenway, Departments of Pediatrics, Cardiac Sciences, Biochemistry & Molecular Biology, Cumming School of Medicine, Libin Cardiovascular Institute of Alberta, Alberta Children’s Hospital Research Institute, University of Calgary, Calgary, AB T2N 4N1, Canada
Author contributions: Both authors contributed to the writing of this paper.
Supported by Children's Cardiomyopathy Foundation.
Conflict-of-interest statement: No potential conflicts of interest.
Open-Access: This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Steven C Greenway, MD, Assistant Professor, Staff Physician, Departments of Pediatrics, Cardiac Sciences, Biochemistry & Molecular Biology, Cumming School of Medicine, Libin Cardiovascular Institute of Alberta, Alberta Children’s Hospital Research Institute, University of Calgary, Calgary, AB T2N 4N1, Canada. scgreenw@ucalgary.ca
Telephone: +1-403-9555049 Fax: +1-403-9557621
Received: March 11, 2019
Peer-review started: March 12, 2019
First decision: June 13, 2019
Revised: June 17, 2019
Accepted: September 22, 2019
Article in press: September 22, 2019
Published online: October 26, 2019
Processing time: 229 Days and 17.4 Hours
Core Tip

Core tip: Several experimental model systems exist for the modeling of cardiomyopathies, including those caused by rare metabolic or mitochondrial diseases. We compare and contrast the cellular models that have been used to date to model several different mitochondrial disorders with a particular focus on the advantages and disadvantages of induced pluripotent stem cells.