Ghosh S, Kapoor D, Vijayvergiya R, Sangwan S, Wangkheimayum S, Mehta S, Dhawan V. Correlation between soluble receptor for advanced glycation end products levels and coronary artery disease in postmenopausal nondiabetic women. World J Cardiol 2021; 13(5): 130-143 [PMID: 34131476 DOI: 10.4330/wjc.v13.i5.130]
Corresponding Author of This Article
Veena Dhawan, PhD, Professor, Department of Experimental Medicine and Biotechnology, PGIMER, Sector-12, Chandigarh 160012, India. officialveenapgi@gmail.com
Research Domain of This Article
Cardiac & Cardiovascular Systems
Article-Type of This Article
Case Control Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Soumitra Ghosh, Rajesh Vijayvergiya, Department ofCardiology, PGIMER, Chandigarh 160012, India
Divya Kapoor, Sonal Sangwan, Sakshi Mehta, Veena Dhawan, Department of Experimental Medicine and Biotechnology, PGIMER, Chandigarh 160012, India
Sujata Wangkheimayum, Department of Biochemistry, PGIMER, Chandigarh 160012, India
Author contributions: Ghosh S designed the research along with collection of samples and analysis; Kapoor D helped in analysis and writing of manuscript; Sangwan S performed the experiments; Study was conducted under the direct supervision of Vijayvergiya R, Wangkheimayum S and Dhawan V; Mehta S and Dhawan V edited and revised the manuscript.
Institutional review board statement: Ethical approval for the study was obtained from the Institute Ethics Committee of the PGIMER, Chandigarh, India, No. INT/IEC/2016/2134.
Informed consent statement: All study participants or their legal guardian provided informed written consent about personal and medical data collection prior to study enrolment.
Conflict-of-interest statement: The authors declare that they have no competing interests.
Data sharing statement: No additional data are available.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Veena Dhawan, PhD, Professor, Department of Experimental Medicine and Biotechnology, PGIMER, Sector-12, Chandigarh 160012, India. officialveenapgi@gmail.com
Received: January 9, 2021 Peer-review started: January 9, 2021 First decision: February 28, 2021 Revised: March 4, 2021 Accepted: April 28, 2021 Article in press: April 28, 2021 Published online: May 26, 2021
ARTICLE HIGHLIGHTS
Research background
The overall risk assessment for coronary artery disease (CAD) in postmenopausal women cannot rely on traditional risk factors. Thus, assessment of novel markers is needed. Receptor for advanced glycation end products (RAGE) interaction is of great importance in diabetic vasculopathy and plays a key role in atherosclerosis.
Research motivation
The motivation was to add to what is known of the role of soluble fraction of RAGE (sRAGE) in Indian postmenopausal women.
Research objectives
The objective was to investigate the association and correlation between plasma levels of sRAGE and CAD in nondiabetic postmenopausal women.
Research methods
This case-control study included 55 angiographically proven CAD subjects with > 50% stenosis of at least one of the major coronary arteries and 55 healthy control women. Plasma sRAGE was determined with an enzyme-linked immunosorbent assay.
Research results
Plasma sRAGE concentrations were significantly lower in subjects with CAD than it was in healthy controls. A significant correlation between plasma sRAGE levels and CAD was observed using univariate and multivariate analysis.
Research conclusions
sRAGE was positively correlated with CAD independent of other traditional risk factors.
Research perspectives
sRAGE can be included in the assessment of CAD-risk in postmenopausal women.
