Case Control Study
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Cardiol. May 26, 2021; 13(5): 130-143
Published online May 26, 2021. doi: 10.4330/wjc.v13.i5.130
Correlation between soluble receptor for advanced glycation end products levels and coronary artery disease in postmenopausal nondiabetic women
Soumitra Ghosh, Divya Kapoor, Rajesh Vijayvergiya, Sonal Sangwan, Sujata Wangkheimayum, Sakshi Mehta, Veena Dhawan
Soumitra Ghosh, Rajesh Vijayvergiya, Department ofCardiology, PGIMER, Chandigarh 160012, India
Divya Kapoor, Sonal Sangwan, Sakshi Mehta, Veena Dhawan, Department of Experimental Medicine and Biotechnology, PGIMER, Chandigarh 160012, India
Sujata Wangkheimayum, Department of Biochemistry, PGIMER, Chandigarh 160012, India
Author contributions: Ghosh S designed the research along with collection of samples and analysis; Kapoor D helped in analysis and writing of manuscript; Sangwan S performed the experiments; Study was conducted under the direct supervision of Vijayvergiya R, Wangkheimayum S and Dhawan V; Mehta S and Dhawan V edited and revised the manuscript.
Institutional review board statement: Ethical approval for the study was obtained from the Institute Ethics Committee of the PGIMER, Chandigarh, India, No. INT/IEC/2016/2134.
Informed consent statement: All study participants or their legal guardian provided informed written consent about personal and medical data collection prior to study enrolment.
Conflict-of-interest statement: The authors declare that they have no competing interests.
Data sharing statement: No additional data are available.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Veena Dhawan, PhD, Professor, Department of Experimental Medicine and Biotechnology, PGIMER, Sector-12, Chandigarh 160012, India.
Received: January 9, 2021
Peer-review started: January 9, 2021
First decision: February 28, 2021
Revised: March 4, 2021
Accepted: April 28, 2021
Article in press: April 28, 2021
Published online: May 26, 2021
Research background

The overall risk assessment for coronary artery disease (CAD) in postmenopausal women cannot rely on traditional risk factors. Thus, assessment of novel markers is needed. Receptor for advanced glycation end products (RAGE) interaction is of great importance in diabetic vasculopathy and plays a key role in atherosclerosis.

Research motivation

The motivation was to add to what is known of the role of soluble fraction of RAGE (sRAGE) in Indian postmenopausal women.

Research objectives

The objective was to investigate the association and correlation between plasma levels of sRAGE and CAD in nondiabetic postmenopausal women.

Research methods

This case-control study included 55 angiographically proven CAD subjects with > 50% stenosis of at least one of the major coronary arteries and 55 healthy control women. Plasma sRAGE was determined with an enzyme-linked immunosorbent assay.

Research results

Plasma sRAGE concentrations were significantly lower in subjects with CAD than it was in healthy controls. A significant correlation between plasma sRAGE levels and CAD was observed using univariate and multivariate analysis.

Research conclusions

sRAGE was positively correlated with CAD independent of other traditional risk factors.

Research perspectives

sRAGE can be included in the assessment of CAD-risk in postmenopausal women.