Saffi MAL, Furtado MV, Polanczyk CA, Montenegro MM, Ribeiro IWJ, Kampits C, Haas AN, Rösing CK, Rabelo-Silva ER. Relationship between vascular endothelium and periodontal disease in atherosclerotic lesions: Review article. World J Cardiol 2015; 7(1): 26-30 [PMID: 25632316 DOI: 10.4330/wjc.v7.i1.26]
Corresponding Author of This Article
Eneida Rejane Rabelo-Silva, RN, ScD, School of Nursing, Federal University of Rio Grande do Sul, Escola de Enfermagem da UFRGS, Rua São Manoel, 963-Santa Cecília, Porto Alegre 90620-110, Brasil. eneidarabelo@gmail.com
Research Domain of This Article
Cardiac & Cardiovascular Systems
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Cardiol. Jan 26, 2015; 7(1): 26-30 Published online Jan 26, 2015. doi: 10.4330/wjc.v7.i1.26
Relationship between vascular endothelium and periodontal disease in atherosclerotic lesions: Review article
Marco Aurélio Lumertz Saffi, Mariana Vargas Furtado, Carisi Anne Polanczyk, Márlon Munhoz Montenegro, Ingrid Webb Josephson Ribeiro, Cassio Kampits, Alex Nogueira Haas, Cassiano Kuchenbecker Rösing, Eneida Rejane Rabelo-Silva
Marco Aurélio Lumertz Saffi, Mariana Vargas Furtado, Carisi Anne Polanczyk, Cardiovascular Division, Hospital de Clínicas de Porto Alegre, Porto Alegre 90035-003, Brazil
Márlon Munhoz Montenegro, Ingrid Webb Josephson Ribeiro, Cassio Kampits, Alex Nogueira Haas, Cassiano Kuchenbecker Rösing, Federal University of Rio Grande do Sul, Faculty of Dentistry, Periodontology, Porto Alegre 90030-035, Brazil
Eneida Rejane Rabelo-Silva, School of Nursing, Federal University of Rio Grande do Sul, Porto Alegre 90620-110, Brazil
Author contributions: All authors had contributed equally to the conception and design of this study; Specific attributions were planned for each author according to his/her institutional position.
Supported by The Fundo de Incentivo à Pesquisa e Eventos (FIPE) at Hospital de Clínicas de Porto Alegre, No. HCPA-120265.
Conflict-of-interest: The authors declare they do not have any competing interest related to this study.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Eneida Rejane Rabelo-Silva, RN, ScD, School of Nursing, Federal University of Rio Grande do Sul, Escola de Enfermagem da UFRGS, Rua São Manoel, 963-Santa Cecília, Porto Alegre 90620-110, Brasil. eneidarabelo@gmail.com
Telephone: +55-51-33598017
Received: September 25, 2014 Peer-review started: September 25, 2014 First decision: October 21, 2014 Revised: November 26, 2014 Accepted: December 18, 2014 Article in press: January 4, 2015 Published online: January 26, 2015
Abstract
Inflammation and endothelial dysfunction are linked to the pathogenesis of atherosclerotic disease. Recent studies suggest that periodontal infection and the ensuing increase in the levels of inflammatory markers may be associated with myocardial infarction, peripheral vascular disease and cerebrovascular disease. The present article aimed at reviewing contemporary data on the pathophysiology of vascular endothelium and its association with periodontitis in the scenario of cardiovascular disease.
Core tip: Recent studies underscore the importance of endothelial dysfunction and inflammatory markers for the development of atherosclerotic disease. In addition, the literature suggests a direct association between periodontal and cardiovascular diseases. Nevertheless, more robust intervention studies are required to clarify specific gaps, especially in relation to the biological and clinical effects of periodontal disease on the genesis and progression of atherosclerotic disease.
