Published online May 26, 2025. doi: 10.4330/wjc.v17.i5.103168
Revised: March 23, 2025
Accepted: April 25, 2025
Published online: May 26, 2025
Processing time: 193 Days and 18.7 Hours
Patients who undergo cardiac surgery often face postoperative pain and potential cognitive issues. Multimodal analgesia may address these problems. We hypo
To investigate the effects of multimodal analgesia on postoperative opioid con
A prospective, randomized controlled trial at General Hospital from January 2020 to April 2023 recruited a total of 150 adult patients who underwent elective cardiac surgery. The patients were randomly divided into two groups. Group A had patient-controlled intravenous analgesia with sufentanil and flurbiprofen axil. Group B had flurbiprofen axil and paravertebral nerve block. Data were analyzed with appropriate statistical methods.
Group B had lower postoperative patient-controlled intravenous analgesia drug consumption (2.21 mL/hour vs 4.26 mL/hour, P < 0.001), shorter extubation time (2.32 hours vs 3.81 hours, P < 0.001), and intensive care unit stay (15.32 h vs 28.63 h, P < 0.001). Visual Analogue Scale pain scores were lower in group B (P < 0.001). Group B had fewer postoperative complications (no respiratory depression vs 37.9% in group A, P < 0.05), a lower postoperative cognitive dysfunction incidence (16.0% vs 28.0%, P < 0.05), and higher Barthel Index scores (P < 0.05).
Multimodal analgesia with paravertebral nerve block and flurbiprofen axil reduces opioid use and improves cognitive outcomes in patients who underwent cardiac surgery.
Core Tip: In this study, 150 patients who underwent cardiac surgery were randomized into two groups. The combination of paravertebral nerve block and flurbiprofen axil in multimodal analgesia significantly reduced postoperative opioid use and enhanced cognitive function. It offered a better pain management and recovery approach.