Editorial
Copyright ©The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Cardiol. Dec 26, 2018; 10(12): 250-253
Published online Dec 26, 2018. doi: 10.4330/wjc.v10.i12.250
Risk of sudden cardiac death: Are coronary chronic total occlusions an additional risk factor?
Ioannis Merinopoulos, Natasha Corballis, Simon C Eccleshall, Vassilios S Vassiliou
Ioannis Merinopoulos, Simon C Eccleshall, Vassilios S Vassiliou, Department of Cardiology, Norfolk and Norwich University Hospital, Norwich NR4 7UY, United Kingdom
Natasha Corballis, Department of Cardiology, West Suffolk Hospital and University of East Anglia, Bury St Edmunds IP33 2QZ, United Kingdom
Vassilios S Vassiliou, Norwich Medical School, University of East Anglia, Norfolk and Norwich University Hospital, Royal Brompton Hospital and Imperial College London, Norwich NR4 7UQ, United Kingdom
Conflict-of-interest statement: The author declares no conflicts of interest regarding this paper.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author to: Vassilios S Vassiliou, FRCP (C), MA, MBBS, MRCP, PhD, Honorory Consultant Cardiologist, Department of Cardiology, Norwich Medical School, Floor 2, Bob Champion Research and Education Building, James Watson Road, Norwich NR4 7UQ, United Kingdom. v.vassiliou@uea.ac.uk
Telephone: +44-16-03592534 Fax: +44-16-03592534
Received: September 13, 2018
Peer-review started: September 13, 2018
First decision: October 16, 2018
Revised: October 23, 2018
Accepted: November 15, 2018
Article in press: November 15, 2018
Published online: December 26, 2018
Processing time: 104 Days and 18.4 Hours
Abstract

Sudden arrhythmic cardiac death remains a significant, potentially reversible, cardiological challenge in terms of creating accurate risk prediction models. The current guidelines for implantable cardioverter defibrillator (ICD) therapy are mainly based on left ventricular ejection fraction despite its low sensitivity and specificity in predicting sudden cardiac death (SCD). Chronic total occlusions have been associated with increased mortality but further research is required to clarify if they should be incorporated in a risk model predicting SCD aiming to identify patients that would benefit from ICD therapy even with preserved ejection fraction.

Keywords: Sudden cardiac death; Chronic total occlusion; Left ventricular ejection fraction; Implantable cardioverter defibrillator

Core tip: Further research is necessary in order to clarify if chronic total occlusion can be incorporated in a risk prediction model of sudden cardiac death aiming to identify patients that would benefit from implantable cardioverter defibrillator.