Copyright ©The Author(s) 2022.
World J Biol Chem. Mar 27, 2022; 13(2): 35-46
Published online Mar 27, 2022. doi: 10.4331/wjbc.v13.i2.35
Table 1 Classes of mRNA targets[2]
Cell cycle regulation
RNA-binding proteins
Histone components
Glucose metabolism
Early embryogenic genes
Cyclin AhnRNP FHistone H2AIGF receptorSox2
CDK4TDP-43Histone H4HInsulin receptorSall4
CCNB1TIA-1Linker histone H1FXHMGA2Oct4
Table 2 Clinical relevance of LIN28A in certain cancers[25]
Primary tumour
Clinical Relevance of LIN28A
BreastHER2 + tumourOverexpression correlated with HER2 + tumours
ColonPrimary adenocarcinomaExpressed in approximately 30% tumours
KidneyPrimary Wilms’ tumourOverexpressed in late stage
LungSmall cell lung cancerLoss increases let-7 levels; inhibits cell cycle
OesophagusPrimary human tumourExpression linked to metastasis and poor prognosis
OvaryPrimary ovarian tumourKnockdown increases let-7 expression