Activated protein C: A regulator of human skin epidermal keratinocyte function

Figure 1 Schematic representation of protein C/activated protein C activation and cellular effects. APC: Activated protein C; EPCR: Endothelial protein C receptor; PC: Protein C; PCI: Protein C inhibitor; TM: Thrombomodulin. Figure was produced using Servier Medical Art - http://www.servier.com.

Figure 2 Schematic representation of the structure of skin showing the epidermal layers. Figure was produced using Servier Medical Art - http://www.servier.com.

Figure 3 Schematic representation of epidermal tight junction complex. JAM: Junctional adhesion molecule; ZO: Zona occludin. Figure was produced using Servier Medical Art - http://www.servier.com.

Figure 4 Immunostaining of protein C/activated protein C in human neonatal and adult skin epidermis. A: Neonatal; B: Adult. PC/APC indicated by brown and green staining in the epidermis (red arrow) and dermal blood vessels (arrow). APC: Activated protein C; PC: Protein C.

Figure 5 Schematic representation of protein C/activated protein C effects on skin epidermal keratinocyte function. APC: Activated protein C; EGFR: Epidermal growth factor receptor; PAR-1: Protease-activated receptor 1. Figure was produced using Servier Medical Art - http://www.servier.com.