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©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Biol Chem. May 26, 2017; 8(2): 129-137
Published online May 26, 2017. doi: 10.4331/wjbc.v8.i2.129
Published online May 26, 2017. doi: 10.4331/wjbc.v8.i2.129
Immunological aspects of age-related diseases
Ken-ichi Isobe, Department of Food Science and Nutrition, Nagoya Woman’s University, Mizuho-ku, Nagoya 467-8610, Japan
Naomi Nishio, Tadao Hasegawa, Department of Bacteriology, Nagoya City University Graduate School of Medical Sciences, Mizuho-ku, Nagoya 466-8550, Japan
Author contributions: All the authors contributed to this manuscript.
Conflict-of-interest statement: There are no conflict of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Ken-ichi Isobe, MD, PhD, Professor, Department of Food Science and Nutrition, Nagoya Woman’s University, 3-40 Shioji-cho, Mizuho-ku, Nagoya 467-8610, Japan. isobe@nagoya-wu.ac.jp
Telephone: +81-52-8529425 Fax: +81-52-8527470
Received: August 22, 2016
Peer-review started: August 24, 2016
First decision: November 19, 2016
Revised: March 2, 2017
Accepted: March 14, 2017
Article in press: March 15, 2017
Published online: May 26, 2017
Peer-review started: August 24, 2016
First decision: November 19, 2016
Revised: March 2, 2017
Accepted: March 14, 2017
Article in press: March 15, 2017
Published online: May 26, 2017
Core Tip
Core tip: The authors divide immune cells, which are involved in age-related pathological changes, into two categories. First category is aging of immune cell-itself, which include age-related myeloid lineage deviation of hematopoietic stem cells, the shrinkage of thymus followed by the decline of naïve T cells, the cytomegalovirus infection-mediated decline of T-cell receptor repertoire diversity and functional decline of myeloid cells. Second category is the involvement of immune cells to age-related pathological changes. Age-related tissue damage and cellular senescence activate pro-inflammatory (M1) macrophages, which induce many age-related diseases. Biochemical works are needed to further elucidate age-related immune changes.