Maru GB, Hudlikar RR, Kumar G, Gandhi K, Mahimkar MB. Understanding the molecular mechanisms of cancer prevention by dietary phytochemicals: From experimental models to clinical trials. World J Biol Chem 2016; 7(1): 88-99 [PMID: 26981198 DOI: 10.4331/wjbc.v7.i1.88]
Corresponding Author of This Article
Girish B Maru, PhD, Honorary Consultant, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre (TMC), Sector-22, Kharghar, Navi Mumbai 410210, India. gmaru@actrec.gov.in
Research Domain of This Article
Biochemistry & Molecular Biology
Article-Type of This Article
Review
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Biol Chem. Feb 26, 2016; 7(1): 88-99 Published online Feb 26, 2016. doi: 10.4331/wjbc.v7.i1.88
Understanding the molecular mechanisms of cancer prevention by dietary phytochemicals: From experimental models to clinical trials
Girish B Maru, Rasika R Hudlikar, Gaurav Kumar, Khushboo Gandhi, Manoj B Mahimkar
Girish B Maru, Rasika R Hudlikar, Gaurav Kumar, Khushboo Gandhi, Manoj B Mahimkar, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre (TMC), Kharghar, Navi Mumbai 410210, India
Author contributions: Maru GB contributed to conception and design of the review/MS; Maru GB, Hudlikar RR, Kumar G, Gandhi K and Mahimkar MB contributed to acquisition of data or analysis, interpretation of data, drafting the article or making critical revisions and final approval of the version of the article to be published.
Conflict-of-interest statement: All authors declare no conflict of interests for this article.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Girish B Maru, PhD, Honorary Consultant, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre (TMC), Sector-22, Kharghar, Navi Mumbai 410210, India. gmaru@actrec.gov.in
Telephone: +91-22-27405022 Fax: +91-22-27405085
Received: June 29, 2015 Peer-review started: July 4, 2015 First decision: August 25, 2015 Revised: October 20, 2015 Accepted: November 23, 2015 Article in press: November 25, 2015 Published online: February 26, 2016
Core Tip
Core tip: Review compares the available evidence on the chemopreventive efficacy and probable mechanisms of chemoprevention by selected dietary phytochemicals in experimental systems and clinical trials. All the dietary phytochemicals covered have demonstrated chemopreventive efficacy against carcinogen-induced tumors in rodents at several organ sites. Mechanism of observed chemopreventive action(s) involve phytochemical-mediated redox changes, modulation of enzymes and signaling kinases leading to effects on multiple genes and cell signaling pathways. Clinical trials with these compounds have not demonstrated their chemopreventive efficacy. Probable reasons for observed mismatch between the two systems and areas of current research efforts and recommendations have been presented.
