Review
Copyright ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Biol Chem. Feb 26, 2016; 7(1): 44-63
Published online Feb 26, 2016. doi: 10.4331/wjbc.v7.i1.44
New insights into sodium transport regulation in the distal nephron: Role of G-protein coupled receptors
Luciana Morla, Aurélie Edwards, Gilles Crambert
Luciana Morla, Aurélie Edwards, Gilles Crambert, Sorbonne Universités, UPMC Univ Paris 06, INSERM, Université Paris Descartes, Sorbonne Paris Cité, UMR_S 1138, Centre de Recherche des Cordeliers, F-75006 Paris, France
Luciana Morla, Aurélie Edwards, Gilles Crambert, CNRS ERL 8228, Centre de Recherche des Cordeliers, Laboratoire de Métabolisme et Physiologie Rénale, F-75006 Paris, France
Luciana Morla, Aurélie Edwards, Gilles Crambert, Centre de Recherche des Cordeliers, INSERM U1138, CNRS ERL 8228, Equipe 3: Métabolisme et Physiologie Rénale, 75270 Paris Cedex, France
Author contributions: All authors contributed to this manuscript.
Conflict-of-interest statement: The authors declare having no conflict of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Gilles Crambert, PhD, Centre de Recherche des Cordeliers, INSERM U1138, CNRS ERL 8228, Equipe 3: Métabolisme et Physiologie Rénale, 15 rue de l’Ecole de Médecine, 75270 Paris Cedex, France. gilles.crambert@crc.jussieu.fr
Telephone: +33-1-44275021
Received: May 28, 2015
Peer-review started: May 28, 2015
First decision: August 4, 2015
Revised: October 2, 2015
Accepted: November 23, 2015
Article in press: November 25, 2015
Published online: February 26, 2016
Core Tip

Core tip: The maintenance of the blood pressure depends partly on the ability of the organism to match the daily intake and excretion of Na+. The kidney, which is the main organ involved in Na+ excretion, is the target of multiple regulatory pathways that contribute to the fine-tuning of secretion/reabsorption processes occurring all along the nephron. In this review we described “classical” and “novel” G-protein coupled receptor (GPCR)-mediated pathways that impact trans-epithelial Na+ transport in the distal nephron. This detailed inventory of the GPCR-mediated pathways that affect renal Na+ handling gives a broad overview of the complexity of this integrated system.