Published online Aug 26, 2015. doi: 10.4331/wjbc.v6.i3.48
Peer-review started: March 3, 2015
First decision: May 13, 2015
Revised: June 4, 2015
Accepted: July 29, 2015
Article in press: August 3, 2015
Published online: August 26, 2015
Core tip: DNA damage may compromise genome integrity and lead to cell death. Cells have evolved a variety of processes to respond to DNA damage including damage repair and tolerance mechanisms. The DNA damage tolerance (DDT) pathway promotes the bypass of single-stranded DNA lesions encountered by DNA polymerases during DNA replication. This prevents the stalling of DNA replication. Two mechanistically distinct DDT branches, translesion synthesis and template switching have been characterized. However, our current understanding of DDT is far from complete and that of template switching is especially sketchy. This editorial focuses on recently identified components and regulators of DDT.