Review
Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Biol Chem. Aug 26, 2015; 6(3): 110-120
Published online Aug 26, 2015. doi: 10.4331/wjbc.v6.i3.110
Biology of hyaluronan: Insights from genetic disorders of hyaluronan metabolism
Barbara Triggs-Raine, Marvin R Natowicz
Barbara Triggs-Raine, Departments of Biochemistry and Medical Genetics, and Pediatrics and Child Health, University of Manitoba, Winnipeg MB R3E 0J9, Canada
Barbara Triggs-Raine, Manitoba Institute of Child Health, Winnipeg MB R3E 3P4, Canada
Marvin R Natowicz, Pathology and Laboratory Medicine, Genomic Medicine, Neurological and Pediatrics Institutes, Cleveland Clinic, Cleveland, OH 44195, United States
Author contributions: Triggs-Raine B conceived and wrote the manuscript; Natowicz MR critically reviewed and revised the manuscript.
Supported by Canadian Institutes of Health Research (to Triggs-Raine B).
Conflict-of-interest statement: The authors have no conflicts of interest to declare related to this research.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Barbara Triggs-Raine, Departments of Biochemistry and Medical Genetics, and Pediatrics and Child Health, University of Manitoba, 745 Bannatyne Ave, Winnipeg MB R3E 0J9, Canada. barbara.triggs-raine@umanitoba.ca
Telephone: +1-204-7893218 Fax: +1-204-7893900
Received: March 27, 2015
Peer-review started: March 28, 2015
First decision: April 27, 2015
Revised: May 8, 2015
Accepted: July 16, 2015
Article in press: July 17, 2015
Published online: August 26, 2015
Core Tip

Core tip: This manuscript summarizes the phenotypes that have been associated with alterations in hyaluronan synthesis or degradation. It should serve as a reference for those who are considering an alteration in hyaluronan metabolism as the cause of a genetic condition.