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©2014 Baishideng Publishing Group Inc. All rights reserved.
World J Biol Chem. Aug 26, 2014; 5(3): 387-397
Published online Aug 26, 2014. doi: 10.4331/wjbc.v5.i3.387
Published online Aug 26, 2014. doi: 10.4331/wjbc.v5.i3.387
Apoptosis induced by Fas signaling does not alter hepatic hepcidin expression
Sizhao Lu, Emily Zmijewski, John Gollan, Duygu Dee Harrison-Findik, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68198-5820, United States
Sizhao Lu, Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198-5820, United States
Author contributions: Lu S designed and performed the experiments; Zmijewski E helped with the experiments; Lu S and Harrison-Findik DD wrote and edited the manuscript; Gollan J helped with manuscript editing.
Supported by NIH grant to Harrison-Findik D, No. R01AA017738; and University of Nebraska Medical Center Graduate Studies Research Fellowship to Lu S
Correspondence to: Duygu Dee Harrison-Findik, Associate Professor, Department of Internal Medicine, University of Nebraska Medical Center, 95820 UNMC, Omaha, NE 68198-5820, United States. dharrisonfindik@unmc.edu
Telephone: +1-402-5596355 Fax: +1-402-5596494
Received: March 6, 2014
Revised: May 7, 2014
Accepted: July 12, 2014
Published online: August 26, 2014
Revised: May 7, 2014
Accepted: July 12, 2014
Published online: August 26, 2014
Core Tip
Core tip: Apoptosis and Fas signaling participate in the pathogenesis of various liver diseases. Iron also contributes to liver injury. Changes in the expression of hepcidin, a key iron regulatory hormone, has been reported in various liver diseases. Recently, apoptosis has been implicated in the regulation of hepcidin. This study investigates effector caspase activation and apoptosis induced by Fas receptor signaling and its relationship to hepatic hepcidin expression.