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World J Biol Chem. Feb 26, 2014; 5(1): 12-25
Published online Feb 26, 2014. doi: 10.4331/wjbc.v5.i1.12
Published online Feb 26, 2014. doi: 10.4331/wjbc.v5.i1.12
Systems biology unravels interferon responses to respiratory virus infections
Andrea L Kroeker, Department of Physiology, University of Manitoba, Winnipeg, MB R3E 0J9, Canada
Kevin M Coombs, Department of Microbiology, University of Manitoba, Winnipeg, MB R3E 0J9, Canada
Author contributions: All authors contributed equally to this work.
Correspondence to: Kevin M Coombs, Professor, Department of Microbiology, University of Manitoba, 730 William Avenue Winnipeg, Winnipeg, MB R3E 0J9, Canada. kevin.coombs@med.umanitoba.ca
Telephone: +1-204-7893976 Fax: +1-204-7893926
Received: October 10, 2013
Revised: December 11, 2013
Accepted: January 6, 2014
Published online: February 26, 2014
Revised: December 11, 2013
Accepted: January 6, 2014
Published online: February 26, 2014
Core Tip
Core tip: Many novel regulators of innate immune signalling pathways, such as the interferon signalling pathway, have been discovered recently. These advances may be in part attributed to high-throughput systems biology techniques including genomic, proteomic, miRNA and siRNA screens, as well as through various confirmatory methods using quantitative polymerase chain reaction, microscopy, and animal models. Collectively, these studies have provided insights into novel drug targets that could boost host innate immunity or could potentially serve as broad-spectrum anti-virals against RNA respiratory viruses.