Basic Study
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Biol Chem. Sep 27, 2022; 13(4): 72-82
Published online Sep 27, 2022. doi: 10.4331/wjbc.v13.i4.72
Profiles of interferon-gamma and interleukin-2 in patients after allogeneic hematopoietic stem cell transplantation
Malwina Rybicka-Ramos, Mirosław Markiewicz, Aleksandra Suszka-Świtek, Ryszard Wiaderkiewicz, Sylwia Mizia, Monika Dzierżak-Mietła, Krzysztof Białas
Malwina Rybicka-Ramos, Department of Hematology, Specialist Hospital No. 1 in Bytom, Bytom 41-902, Poland
Mirosław Markiewicz, Department of Hematology, University of Rzeszow, College of Medical Sciences, Institute of Medical Sciences, Rzeszów 35-315, Poland
Aleksandra Suszka-Świtek, Ryszard Wiaderkiewicz, Department of Histology and Embryology, School of Medicine in Katowice, Medical University of Silesia, Katowice 40-752, Poland
Sylwia Mizia, Department of Population Health, Division of Epidemiology and Health Education, Wroclaw Medical University, Wrocław 51-618, Poland
Monika Dzierżak-Mietła, Department of Bone Marrow Transplantation and Hematooncology, Maria Sklodowska-Curie National Research Institute of Oncology, Gliwice 44-102, Poland
Krzysztof Białas, Department of Hematology and Bone Marrow Transplantation, SPSK-M Hospital, Katowice 40-027, Poland
Author contributions: Rybicka-Ramos M contributed to conceptualization, methodology, investigation, data curation and analysis, original draft preparation, project administration, and fund acquisition; Markiewicz M contributed to methodology, investigation, manuscript review and editing, supervision, and fund acquisition; Dzierzak-Mietla M and Bialas K contributed to investigation; Suszka-Świtek A, Wiaderkiewicz R, and Mizia S contributed to data curation and analysis.
Institutional review board statement: The study was conducted according to the guidelines of the Declaration of Helsinki, and approved by the Ethics Committee of the Medical University of Silesia in Katowice (No. KNW/0022/KB1/71/I/12).
Conflict-of-interest statement: All the authors declare no conflict of interest for this article.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Malwina Rybicka-Ramos, MD, PhD, Doctor, Department of Hematology, Specialist Hospital No. 1 in Bytom, 7 Zeromskiego Street, Bytom 41-902, Poland.
Received: March 8, 2022
Peer-review started: March 8, 2022
First decision: April 25, 2022
Revised: May 11, 2022
Accepted: September 21, 2022
Article in press: September 21, 2022
Published online: September 27, 2022
Core Tip

Core Tip: This paper presents the profiles of interleukin-2 and interferon-gamma levels depending on the occurrence of acute graft-versus-host disease and infection complications after allogeneic hematopoietic stem cell transplantation (allo-HSCT). In this study, the cytokine levels were assessed in the early period after allo-HSCT (within the first 30 d after transplantation). Before, during, and after blood sampling for cytokine determination, cytokine-producing cells were not stimulated with mitogenic substances (lipopolysaccharide or phytohemagglutinin). Therefore, the obtained cytokine levels and their profiles may be regarded as those which reflect real values in patients who underwent allo-HSCT.