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©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Biol Chem. Nov 27, 2020; 11(3): 99-111
Published online Nov 27, 2020. doi: 10.4331/wjbc.v11.i3.99
Published online Nov 27, 2020. doi: 10.4331/wjbc.v11.i3.99
Deciphering the modifiers for phenotypic variability of X-linked adrenoleukodystrophy
Shruti V Palakuzhiyil, Rita Christopher, Department of Neurochemistry, National Institute of Mental Health and Neuro Sciences, Bengaluru 560029, India
Sadanandavalli Retnaswami Chandra, Department of Neurology, Sri Ramakrishna Ashram Charitable Hospital, Trivandrum 695010, India
Author contributions: All the authors have contributed equally to the preparation of the manuscript.
Supported by Department of Biotechnology , New Delhi, India. No. BT/PR26150/MED/12/768/2017.
Conflict-of-interest statement: The authors declare no conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Rita Christopher, MD, Professor, Department of Neurochemistry, National Institute of Mental Health and Neuro Sciences, Hosur Road, Bengaluru 560029, India. rita.nimhans@yahoo.com
Received: June 4, 2020
Peer-review started: June 4, 2020
First decision: July 4, 2020
Revised: July 10, 2020
Accepted: September 18, 2020
Article in press: September 18, 2020
Published online: November 27, 2020
Peer-review started: June 4, 2020
First decision: July 4, 2020
Revised: July 10, 2020
Accepted: September 18, 2020
Article in press: September 18, 2020
Published online: November 27, 2020
Core Tip
Core Tip: The monogenic peroxisomal disorder, X-linked adrenoleukodystrophy (X-ALD), presents with different clinical phenotypes. The molecular basis for the phenotypic variation has yet to be resolved and is considered to be influenced by genetic, epigenetic, cellular, or environmental factors. We herein discuss the various modifying factors, which can potentially alter the phenotypic presentation of X-ALD.