Published online May 26, 2013. doi: 10.4331/wjbc.v4.i2.16
Revised: April 23, 2013
Accepted: April 28, 2013
Published online: May 26, 2013
The philosophy of heart and brain are very ancient in our literature where the things good for the heart are not suggested good for the brain and vice-versa. Modern medicine is characterized by a high degree of specialization and the heart-brain connection that could be targeted to treat these complex cardiovascular/brain disorders. The idea that adverse diet/genome interactions can cause disease is not new. In the recent era the science of nutritional genomics have increased our understanding of diet-health-gene interactions and have provided a number of benefits for individuals, groups and societies. Since dietary chemicals are regularly ingested and participate indirectly and directly in regulating gene expression, it follows that a subset of genes regulated by diet must be involved in disease initiation, progression, and severity. In this regards Liver X Receptor (LXR)-α, a key transcription factors, associated with the several chronic pathological situation including coronary heart disease and neurodegenerative diseases have recently been found to be regulated by the dietary components. The crucial findings at molecular biology unit, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, INDIA have not only forced us to explore nutritional genomics as a holistic systems approach to understand the relationship between diet and health, but also to look into the disease preventing and health promoting foods that match our lifestyles, cultures and genetics. After all, we are what we eat.
Core tip: The progression from a healthy phenotype to a chronic disease phenotype comes into existence by abnormal regulation of gene expression, influenced by the dietary components and gene environment interaction. Liver X Receptor-α is one of the key transcription factor which is modulated by the dietary components such as oxycholesterol, withaferin A, vitamin C, vitamin D and statins. Thus the molecule attracts its role in the field of neutro-genomics.