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©2011 Baishideng Publishing Group Co., Limited. All rights reserved.
World J Biol Chem. Jun 26, 2011; 2(6): 108-114
Published online Jun 26, 2011. doi: 10.4331/wjbc.v2.i6.108
Published online Jun 26, 2011. doi: 10.4331/wjbc.v2.i6.108
Role of Ikaros in T-cell acute lymphoblastic leukemia
Philippe Kastner, Susan Chan, Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch 67400, France;
Philippe Kastner, Susan Chan, INSERM U964, Illkirch 67400, France
Philippe Kastner, Susan Chan, CNRS UMR7104, Illkirch 67400, France; Université de Strasbourg, Strasbourg 67000, France
Author contributions: Kastner P and Chan S wrote the paper.
Supported by Institut National du Cancer, La Ligue Contre le Cancer (équipe labellisée), l’Agence Nationale de la Recherche, l’Association pour la Recherche sur le Cancer and La Fondation de France, with institute funding from INSERM, CNRS and l’Université de Strasbourg
Correspondence to: Philippe Kastner, PhD, Institut de Génétique et de Biologie Moléculaire et Cellulaire, 1 rue Laurent Fries, Illkirch 67404, France. scpk@igbmc.fr
Telephone: +33-3-88653461 Fax: +33-3-88653201
Received: March 22, 2011
Revised: April 27, 2011
Accepted: June 3, 2011
Published online: June 26, 2011
Revised: April 27, 2011
Accepted: June 3, 2011
Published online: June 26, 2011
Abstract
Ikaros is a zinc finger transcriptional regulator encoded by the Ikzf1 gene. Ikaros displays crucial functions in the hematopoietic system and its loss of function has been linked to the development of lymphoid leukemia. In particular, Ikaros has been found in recent years to be a major tumor suppressor involved in human B-cell acute lymphoblastic leukemia. Its role in T-cell leukemia, however, has been more controversial. While Ikaros deficiency appears to be very frequent in murine T-cell leukemias, loss of Ikaros appears to be rare in human T-cell acute lymphoblastic leukemia (T-ALL). We review here the evidence linking Ikaros to T-ALL in mouse and human systems.
Keywords: Ikaros, Notch, T-cell leukemia