Plasma membrane Ca2+-ATPases in the nervous system during development and ageing

doi:10.4331/wjbc.v1.i7.229

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Jul 26, 2010 (publication date) through May 7, 2024

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World Journal of Biological Chemistry

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1949-8454

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Biol Chem. Jul 26, 2010; 1(7): 229-234
Published online Jul 26, 2010. doi: 10.4331/wjbc.v1.i7.229

Plasma membrane Ca²⁺-ATPases in the nervous system during development and ageing

Ana M Mata, M Rosario Sepulveda

Ana M Mata, M Rosario Sepulveda, Department of Biochemistry and Molecular Biology and Genetics, Faculty of Sciences, University of Extremadura, 06006 Badajoz, Spain

Author contributions: Both authors performed some of the work described in the review and wrote the manuscript.

Supported by Grants No. BFU2008-00182 from MICINN, Fundaci¨®n Marcelino Botín, Spain (to Mata AM); Sepulveda MR received a Postdoctoral Fellowship from Programa de Reincorporaci¨®n de Doctores, Junta de Extremadura, Spain

Correspondence to: Ana M Mata, PhD, Professor, Department of Biochemistry and Molecular Biology and Genetics, Faculty of Sciences, University of Extremadura, 06006 Badajoz, Spain. anam@unex.es

Telephone: +34-924-289418 Fax: +34-924-289419

Received: May 27, 2010
Revised: July 1, 2010
Accepted: July 8, 2010
Published online: July 26, 2010

Abstract

Calcium signaling is used by neurons to control a variety of functions, including cellular differentiation, synaptic maturation, neurotransmitter release, intracellular signaling and cell death. This review focuses on one of the most important Ca²⁺ regulators in the cell, the plasma membrane Ca²⁺-ATPase (PMCA), which has a high affinity for Ca²⁺ and is widely expressed in brain. The ontogeny of PMCA isoforms, linked to specific requirements of Ca²⁺ during development of different brain areas, is addressed, as well as their function in the adult tissue. This is based on the high diversity of variants in the PMCA family in brain, which show particular kinetic differences possibly related to specific localizations and functions of the cell. Conversely, alterations in the activity of PMCAs could lead to changes in Ca²⁺ homeostasis and, consequently, to neural dysfunction. The involvement of PMCA isoforms in certain neuropathologies and in brain ageing is also discussed.

Keywords: Calcium, Brain, ATPase, Plasma membrane, Differentiation, Neurodegeneration