Gastric metastasis from renal cell carcinoma with a 10-year interval: A case report

doi:10.4240/wjgs.124761

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World Journal of Gastrointestinal Surgery

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1948-9366

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Case Report

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastrointest Surg. Nov 27, 2026; 18(11): 124761
Published online Nov 27, 2026. doi: 10.4240/wjgs.124761

Table 1 Immunohistochemistry profile of the gastric lesion: Confirming metastatic clear cell renal cell carcinoma

Marker	Result (this case)	ccRCC (typical)	Gastric adenocarcinoma (typical)	Diagnostic implication
PAX-8	+	+	-	Establishes renal lineage; excludes gastric primary
CA IX	+	+	-	ccRCC molecular hallmark; VHL/HIF pathway activation
CD10	+	+	-	Supports proximal nephron origin
CK7	-	-	+	Rules out gastric, pancreatobiliary, pulmonary origin

ccRCC: Clear cell renal cell carcinoma; CA IX: Carbonic anhydrase IX; CK: Cytokeratin; CD10: Cluster of differentiation 10; +: Positive; -: Negative; VHL: Von Hippel-Lindau; HIF: Hypoxia-inducible factor.

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Citation: Gao TZ, Zheng CZ, Zhu KK, Wu XN, He CY, Lou YM, Liu XS. Gastric metastasis from renal cell carcinoma with a 10-year interval: A case report. World J Gastrointest Surg 2026; 18(11): 124761
URL: https://www.wjgnet.com/1948-9366/full/v18/i11/124761.htm
DOI: https://dx.doi.org/10.4240/wjgs.124761

Gao TZ, Zheng CZ, Zhu KK, Wu XN, He CY, Lou YM, Liu XS. Gastric metastasis from renal cell carcinoma with a 10-year interval: A case report. World J Gastrointest Surg 2026; 18(11): 124761 [DOI: 10.4240/wjgs.124761]

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