Anal adenocarcinoma with perianal Paget's disease: A case report

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Aug 27, 2025 (publication date) through Aug 28, 2025

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World Journal of Gastrointestinal Surgery

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1948-9366

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Surg. Aug 27, 2025; 17(8): 108963
Published online Aug 27, 2025. doi: 10.4240/wjgs.v17.i8.108963

Table 1 Shutze and Gleysteen staging system and treatment recommendations for perianal Paget's disease

Stage	Description	Treatment recommendation
I	Paget cells confined to perianal dermis and its appendages without carcinoma in situ	WLE
II	Paget's disease of epidermis with associated appendageal carcinoma	WLE
III	Paget's disease with concurrent rectal/anal canal carcinoma	APR
IV	Paget's disease with regional lymph node metastasis	APR + regional lymphadenectomy
V	Paget's disease with distant organ metastasis	Chemoradiotherapy + local palliative therapy

WLE: Wide local excision; APR: Abdominoperineal resection.

Citation: Wu SW, Rong Y, Chen GJ, Cao XS, Xie ZY, Wu B, Huang HC, Wang ZW, Wu XX. Anal adenocarcinoma with perianal Paget's disease: A case report. World J Gastrointest Surg 2025; 17(8): 108963
URL: https://www.wjgnet.com/1948-9366/full/v17/i8/108963.htm
DOI: https://dx.doi.org/10.4240/wjgs.v17.i8.108963