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©The Author(s) 2025.
World J Gastrointest Surg. Jun 27, 2025; 17(6): 103635
Published online Jun 27, 2025. doi: 10.4240/wjgs.v17.i6.103635
Published online Jun 27, 2025. doi: 10.4240/wjgs.v17.i6.103635
Table 1 Patient characteristics in the study, n (%)
Characteristics | Total (n = 260) | CEMR (n = 130) | UEMR (n = 130) | P value |
Age, median (minimum-maximum) | 58 (27-85) | 60 (27-83) | 59 (32-85) | 0.9152 |
Sex | 0.699 | |||
Male | 165 (63.5) | 84 (64.6) | 81 (62.3) | |
Female | 95 (36.5) | 46 (35.4) | 49 (37.7) | |
Indication for colonoscopy | ||||
Abdominal pain | 73 (28.1) | 42 (32.3) | 31 (23.8) | 0.129 |
Screening | 60 (23.1) | 24 (18.5) | 36 (27.7) | 0.077 |
Blood in stool | 34 (13.1) | 15 (11.5) | 19 (14.6) | 0.462 |
Diarrhea | 33 (12.7) | 17 (13.1) | 16 (12.3) | 0.852 |
Constipation | 33 (12.7) | 17 (13.1) | 16 (12.3) | 0.852 |
Post-operative CRC | 23 (8.8) | 14 (10.8) | 9 (6.9) | 0.275 |
Stool change | 2 (0.8) | 0 (0) | 2 (1.5) | 0.4981 |
Weight loss | 2 (0.8) | 1 (0.8) | 1 (0.8) | 11 |
Clinical symptoms | ||||
No symptom | 85 (32.7) | 38 (29.3) | 47 (36.1) | 0.234 |
Abdominal pain | 74 (28.5) | 40 (30.8) | 34 (26.2) | 0.410 |
Diarrhea | 35 (13.5) | 19 (14.6) | 16 (12.3) | 0.586 |
Blood in stool | 33 (12.7) | 17 (13.1) | 16 (12.3) | 0.852 |
Constipation | 31 (11.9) | 15 (11.5) | 16 (12.3) | 0.848 |
Weight loss | 2 (0.8) | 1 (0.8) | 1 (0.8) | 11 |
Hypertension | 127 (48.8) | 62 (47.7) | 65 (50) | 0.710 |
Diabetes | 20 (7.7) | 8 (6.2) | 12 (9.2) | 0.352 |
Kidney failure | 3 (1.2) | 0 (0) | 3 (2.3) | 0.2471 |
Personal history of CRC | 11 (4.2) | 5 (3.8) | 6 (4.6) | 0.758 |
Family history of CRC | 4 (1.5) | 2 (1.5) | 2 (1.5) | 11 |
Table 2 Endoscopic and pathological characteristics of the colorectal lesions, n (%)
Characteristics | Total (n = 260) | CEMR (n = 130) | UEMR (n = 130) | P value |
Location of lesion | ||||
Rectum | 67 (25.8) | 28 (21.5) | 39 (30.0) | 0.119 |
Sigmoid colon | 98 (37.7) | 52 (40.0) | 46 (35.4) | 0.443 |
Descending colon | 16 (6.2) | 10 (7.7) | 6 (4.6) | 0.302 |
Transverse colon | 34 (12.3) | 17 (13.1) | 17 (13.1) | 1 |
Ascending colon | 36 (13.8) | 18 (13.8) | 18 (13.8) | 1 |
Cecum | 9 (3.5) | 5 (3.8) | 4 (3.1) | 11 |
Size, median (minimum-maximum) (mm) | 20 (10-30) | 12 (10-30) | 12 (10-25) | 0.7582 |
10-19 | 233 (89.6) | 117 (90.0) | 116 (89.2) | 0.839 |
20-30 | 27 (10.4) | 13 (10.0) | 14 (10.8) | |
Paris classification | 0.600 | |||
0-Is | 172 (66.1) | 88 (67.7) | 84 (64.6) | |
0-IIa/0-IIb | 88 (33.9) | 42 (32.3) | 46 (35.4) | |
NICE classification | 0.656 | |||
Type 1 | 22 (8.5) | 10 (7.7) | 12 (9.2) | |
Type 2 | 238 (91.5) | 120 (92.3) | 118 (90.8) | |
WHO classification | ||||
Nonneoplastic polyp | 14 (5.4) | 6 (4.6) | 8 (6.2) | 0.583 |
Tubular adenoma | 161 (61.9) | 76 (58.5) | 85 (65.4) | 0.250 |
Tubulo-villous adenoma | 36 (13.8) | 21 (16.2) | 15 (11.5) | 0.281 |
Serrated lesion | 49 (18.8) | 27 (20.8) | 22 (16.9) | 0.428 |
Vienna classification | ||||
No dysplasia | 21 (8.1) | 9 (6.9) | 12 (9.2) | 0.495 |
Low-grade dysplasia | 209 (80.4) | 108 (83.1) | 101 (77.7) | 0.274 |
High-grade dysplasia | 26 (10.0) | 10 (7.7) | 16 (12.3) | 0.215 |
Superficial cancer | 4 (1.5) | 3 (2.3) | 1 (0.8) | 0.6221 |
Table 3 Study outcomes (intention-to-treat analysis), n (%)
Table 4 Study outcomes (per-protocol analysis), n (%)
- Citation: Le QD, Le NQ, Quach DT. Underwater vs conventional endoscopic mucosal resection for nonpedunculated colorectal neoplasms: A randomized controlled trial. World J Gastrointest Surg 2025; 17(6): 103635
- URL: https://www.wjgnet.com/1948-9366/full/v17/i6/103635.htm
- DOI: https://dx.doi.org/10.4240/wjgs.v17.i6.103635