Endoscopic anti-reflux mucosal resection for patients with gastroesophageal reflux disease: Clinical efficacy and impact on gut microbiota

Table 1 Baseline clinical data of included patients, mean ± SD

Variable	Patients (n = 80)	Percentage (%)
Sex
Male	58	72.5
Female	22	27.5
Age (years)	52.18 ± 7.56
BMI (kg/m2)	23.87 ± 3.25
Average Gerd Q score (points)	11.32 ± 1.26
History of PPIs use	80	100.0
Mucosal resection range
Full circumference	2	2.5
3/4 circumference	42	52.5
1/2 circumference	36	45.0
Median operative time (minutes)	48.5 (21, 122)

BMI: Body mass index; PPIs: Proton pump inhibitor.

Table 2 Comparison of the gut microbiota before and after operation, mean ± SD

Index	Before operation	Three months after surgery	t value	P value
Bifidobacterium	4.95 ± 1.02	8.92 ± 1.03	24.496	< 0.001
Lactobacillus	6.57 ± 0.81	8.87 ± 0.88	17.200	< 0.001
Escherichia coli	7.65 ± 0.68	6.74 ± 0.42	10.184	< 0.001
Staphylococcus	8.76 ± 1.15	7.32 ± 0.81	9.157	< 0.001

Table 3 Incidence of postoperative adverse reactions

Index	Patients (n = 80)	Percentage (%)
Severe dysphagia	12	15.0
Delayed bleeding	4	5.0
Total incidence	16	20.0