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©The Author(s) 2025.
World J Gastrointest Surg. Jun 27, 2025; 17(6): 102907
Published online Jun 27, 2025. doi: 10.4240/wjgs.v17.i6.102907
Published online Jun 27, 2025. doi: 10.4240/wjgs.v17.i6.102907
Table 1 Comparison of Visual Analogy Scale levels among different groups after surgery, n = 30 for each group
Time point | Youth control group | Youth observation group | Elderly control group | Elderly observation group | t | P value |
2 hours post-surgery | 4.35 ± 0.87 | 3.55 ± 0.74 | 4.15 ± 0.85 | 3.45 ± 0.70 | 2.581 | 0.012 |
6 hours post-surgery | 3.75 ± 0.82 | 2.85 ± 0.68 | 3.55 ± 0.80 | 2.75 ± 0.65 | 3.511 | 0.001 |
12 hours post-surgery | 3.30 ± 0.75 | 2.60 ± 0.64 | 3.10 ± 0.78 | 2.50 ± 0.59 | 4.256 | < 0.001 |
24 hours post-surgery | 2.90 ± 0.70 | 2.20 ± 0.60 | 2.80 ± 0.73 | 2.05 ± 0.57 | 4.341 | < 0.001 |
48 hours post-surgery | 2.60 ± 0.65 | 2.00 ± 0.59 | 2.40 ± 0.66 | 1.90 ± 0.58 | 3.731 | 0.003 |
Table 2 Comparison of postoperative Montreal Cognitive Assessment scores among different groups, n = 30 for each group
Time point | Youth control group | Youth observation group | Elderly control group | Elderly observation group | t | P value |
1 day before surgery | 27.80 ± 1.08 | 27.75 ± 1.12 | 27.40 ± 1.22 | 27.25 ± 1.06 | 0.521 | 0.611 |
1 day post-surgery | 25.20 ± 1.54 | 23.10 ± 1.60 | 24.20 ± 1.49 | 22.00 ± 1.69 | 3.437 | 0.002 |
3 days post-surgery | 25.40 ± 1.43 | 23.80 ± 1.58 | 24.80 ± 1.40 | 23.10 ± 1.60 | 2.983 | 0.007 |
7 days post-surgery | 26.20 ± 1.30 | 24.60 ± 1.45 | 25.80 ± 1.38 | 24.40 ± 1.56 | 3.205 | 0.003 |
Table 3 Comparison of serum inflammatory factor levels between two groups
Time point | Group | IL-6 (pg/mL) | TNF-α (pg/mL) | CRP (mg/L) |
1 day before surgery | Observation | 12.45 ± 3.15 | 8.73 ± 2.22 | 3.45 ± 1.02 |
Control | 12.39 ± 3.09 | 8.69 ± 2.18 | 3.42 ± 0.98 | |
6 hours after surgery | Observation | 26.78 ± 5.32 | 16.45 ± 3.47 | 7.89 ± 2.15 |
Control | 35.12 ± 6.48 | 22.67 ± 4.56 | 10.34 ± 2.87 | |
24 hours after surgery | Observation | 18.65 ± 4.08 | 12.34 ± 2.98 | 5.23 ± 1.65 |
Control | 25.78 ± 5.21 | 17.89 ± 3.84 | 7.68 ± 2.12 | |
48 hours after surgery | Observation | 14.32 ± 3.67 | 10.12 ± 2.45 | 4.12 ± 1.34 |
Control | 19.65 ± 4.35 | 13.78 ± 3.12 | 5.89 ± 1.78 | |
Time main effect F value | 87.452 | 92.678 | 79.345 | |
Time main effect P value | < 0.001 | < 0.001 | < 0.001 | |
Group main effect F value | 36.541 | 41.763 | 34.217 | |
Group main effect P value | < 0.001 | < 0.001 | < 0.001 | |
Interaction F value | 9.328 | 10.456 | 8.974 | |
Interaction P value | < 0.001 | < 0.001 | < 0.001 |
Table 4 Comparison of serum stress hormone levels between two groups
Time point | Group | Cor (nmol/L) | t | P value | AD (ng/mL) | t | P value |
1 day before surgery | Observation | 295.45 ± 36.25 | -0.118 | 0.906 | 15.23 ± 3.45 | -0.344 | 0.731 |
Control | 296.23 ± 35.78 | 15.45 ± 3.56 | |||||
6 hours after surgery | Observation | 450.32 ± 40.12 | -7.973 | < 0.001 | 25.32 ± 4.67 | -6.096 | < 0.001 |
Control | 512.67 ± 45.34 | 30.78 ± 5.12 | |||||
24 hours after surgery | Observation | 395.65 ± 38.78 | -6.949 | < 0.001 | 22.45 ± 4.12 | -6.671 | < 0.001 |
Control | 445.89 ± 40.56 | 27.89 ± 4.78 | |||||
48 hours after surgery | Observation | 320.45 ± 35.34 | -5.198 | < 0.001 | 18.45 ± 3.67 | -4.653 | < 0.001 |
Control | 355.67 ± 38.78 | 21.67 ± 3.89 |
Table 5 Comparison of adverse reactions between two groups, n (%)
Time point | Group | Nausea | Vomit | Headache | Hypotension | Local numbness | χ2 | P value |
6 hours after surgery | Observation | 3 (5.00) | 2/3.33 | 1 (1.67) | 4 (6.67) | 2 (3.33) | 1.087 | 0.9 |
Control | 4 (6.67) | 3/5.00 | 2 (3.33) | 5 (8.33) | 3 (5.00) | |||
24 hours after surgery | Observation | 2 (3.33) | 1/1.67 | 0 | 2 (3.33) | 1 (1.67) | 2.066 | 0.733 |
Control | 3 (5.00) | 2/3.33 | 1 (1.67) | 3 (5.00) | 2 (3.33) | |||
48 hours after surgery | Observation | 1 (1.67) | 1/1.67 | 0 | 1 (1.67) | 1 (1.67) | 1.667 | 0.798 |
Control | 2 (3.33) | 2/3.33 | 1 (1.67) | 2 (3.33) | 2 (3.33) |
Table 6 Comparison of nuclear factor κB activity levels between two groups after surgery
Group | 24 hours phosphorylated p65 level (relative value) | 48 hours phosphorylated p65 level (relative value) | 72 hours phosphorylated p65 level (relative value) | 96 hours phosphorylated p65 level (relative value) | 120 hours phosphorylated p65 level (relative value) | F value | P value |
Control group | 1.05 ± 0.12 | 1.25 ± 0.15 | 1.40 ± 0.18 | 1.50 ± 0.20 | 1.60 ± 0.22 | ||
Observation group | 0.75 ± 0.10 | 0.55 ± 0.08 | 0.45 ± 0.07 | 0.35 ± 0.06 | 0.30 ± 0.05 | 24.539 | < 0.001 |
P value | 0.02 | 0.001 | < 0.001 | < 0.001 | < 0.001 |
- Citation: Zhang X, Xiang GR, Wang ZX, Peng MQ, Li M. Effect of dexmedetomidine-ropivacaine transversus abdominis plane block on analgesia and cognitive impairment risk in colorectal cancer surgery. World J Gastrointest Surg 2025; 17(6): 102907
- URL: https://www.wjgnet.com/1948-9366/full/v17/i6/102907.htm
- DOI: https://dx.doi.org/10.4240/wjgs.v17.i6.102907