Opinion Review
Copyright ©The Author(s) 2021.
World J Gastrointest Surg. Jul 27, 2021; 13(7): 620-632
Published online Jul 27, 2021. doi: 10.4240/wjgs.v13.i7.620
Table 1 Etiology of gastric outlet obstruction[1,2]
Malignant causesBenign causes
Pancreatic cancerPeptic ulcer
Gastric cancerHypertrophic pyloric obstruction
CholangiocarcinomaGastric polyp
Gallbladder cancerCaustic ingestion
Duodenal cancerIatrogenic
Ampullary cancerGastric/duodenal tuberculosis
Other1Prepyloric web
Table 2 Gastric outlet obstruction scoring system[3]
Level of oral intakeScore
No oral intake0
Liquids only1
Soft solids2
Low residue or full diet3
Table 3 Types of lumen-apposing metal stents[27-29]
StentFlange diameter (mm)Length (mm)Lumen diameter (mm)Electrocautery enhanced option Material
AXIOSTM (Boston Scientific Corp., Marlborough, MA, United States)21, 24, 291010, 15, 20YesSilicone-covered, nitinol-braided stent
NAGITM (Taewoong Medical Co., Ltd., Goyang, South Korea)2010, 20, 3010, 12, 14, 16NoSilicone-covered, Nitinol stent
Niti-S SpaxusTM stent (Taewoong Medical Co., Ltd.)23, 25, 31208, 10, 16YesSilicone-covered, Nitinol stent
HANAROTM stent (M.I.Tech, Pyeongtaek, South Korea)22 - 2810, 3010, 12, 14, 16NoSilicone-covered, Nitinol stent
Table 4 Outcomes of endoscopic ultrasonography-guided gastroenterostomy using a lumen-apposing self-expandable metal stent in benign and malignant gastric outlet obstruction[27,30,35-40]
Itoi et al[30]Tyberg et al[35]Chen et al[36]Kerdsirichairat et al[38] Ge et al[37]Jovani et al[39]Wannhoff et al[27]James et al[40]
Type of studySingle-center, ProspectiveInternational, RetrospectiveMulticenter, RetrospectiveSingle-center, RetrospectiveSingle-center, RetrospectiveSingle-center, RetrospectiveSingle-center, RetrospectiveSingle-center, Retrospective
Number of patients (n)2026745722733522
Number of malignant obstructions201749482264330
Number of benign obstructions0925909222
EUS-GJ technique, nEPASS n = 20Direct n = 3, Balloon-assisted n = 13, Nasobiliary n = 3, Ultraslim scope n = 5, NOTES n = 2Direct n =52Balloon-assisted n = 22Direct n = 57Direct n = 24Direct n = 73Direct n = 22, Nasobiliary n = 10, other = 3Direct n = 9, Orojejunal = 5, Balloon-assisted = 8
Technical success (%)909294.290.992.9100938095.4
Clinical success (%)NA8592.390.989.595.89774.3NA
Adverse events (%)1011.55.89.13.520.87.414.319
Recurrence/need for Reintervention (%)NA3.85.818.215.1815NA23.8
Table 5 Outcomes of endoscopic ultrasonography-guided gastroenterostomy using a lumen-apposing self-expandable metal stent as compared to surgery[41,42]
Khashab et al[41]Perez-Miranda et al[42]
Type of studyMulticenter, retrospective Multicenter, retrospective
GroupEUS-GJSurgeryEUS-GJLaparoscopic GJ
Number of patients, n (%)30/93 (32.3)63/93 (67.7)25/54 (46.3)29/54 (53.7)
TechniqueDirect; EPASS; Balloon-assistedOpen GJ2Direct AssistedLaparoscopic GJ
Technical success (%)8710088100
Clinical success (%)87908490
Adverse events (%)16251241
Recurrence/need for Reintervention (%)314NANA
Table 6 Outcomes of endoscopic ultrasonography-guided gastroenterostomy using a lumen-apposing self-expandable metal stent as compared to duodenal stenting[37,43]
Chen et al[43]Ge et al[37]
Type of studyMulticenter, retrospective Single center, retrospective
GroupEUS-GJDuodenal stentingEUS-GJDuodenal stenting
Number of patients, n (%)30 (36.5)52 (63.4)22 (22)78 (78)
TechniqueDirect; EPASS; Balloon-assistedUncovered Wallflex (Boston Scientific)Direct AssistedUncovered WallFlex; Boston Scientific, or (Evolution; Cook Medical)
Technical success (%)86.794.2100100
Clinical success (%)83.367.395.876.3
Adverse events (%)16.711.520.840.2
Recurrence/need for Reintervention (%)4.028.6832