Copyright ©The Author(s) 2016.
World J Gastrointest Surg. Feb 27, 2016; 8(2): 115-123
Published online Feb 27, 2016. doi: 10.4240/wjgs.v8.i2.115
Figure 1
Figure 1 The aryl hydrocarbon receptor signaling pathway is depicted with 3,3′-diindolylmethane as a model agonist. Upon binding to a ligand, aryl hydrocarbon receptor (AHR) sheds its cytosolic chaperones and translocates to the nucleus to heterodimerize with aryl hydrocarbon receptor nuclear translocator (ARNT). This complex binds to the xenobiotic response element (XRE) within the genome and drives transcription of cytochrome P450 detoxifying enzymes. Proposed avenues of cross-talk with inflammatory bowel disease pathology are listed. IBD : Inflammatory bowel disease.