Post-operative abdominal complications in Crohn’s disease in the biological era: Systematic review and meta-analysis

Figure 1 Preferred reporting items for systematic reviews and meta-analyses reporting diagram. IBD: Inflammatory bowel disease.

Figure 2 Total infectious complications: Study event rates and forest plot. Forest plot showing significantly higher total infective complications in patients receiving biological therapy - note confidence interval does not overlap one.

Figure 3 Postoperative abdominal sepsis: Study event rates and forest plot.

Figure 4 Anastomotic leak: Study event rates and forest plot.

Figure 5 Wound infection: Study event rates and forest plot. Lone outlier study (Uchino 2013) visible on forest plot.

Figure 6 Wound infection: Funnel plot with outlier. A single statistical outlier visible outside the funnel plot suggestive of possible publication bias.

Figure 7 Wound infection: Modified study event rates and forest plot.

Figure 8 Re-operation: Study event rates and forest plot.